Статья
РАДИОНУКЛИДНЫЕ МЕТОДЫ В ДИАГНОСТИКЕ АМИЛОИДОЗА СЕРДЦА
Золотым стандартом в диагностике амилоидоза сердца остается гистологический анализ эндомиокарда. Учитывая ограничения этого подхода, существует потребность в неинвазивных методиках диагностики амилоидоза сердца. Изменения миокарда, видимые при эхокардиографии и магнитной резонансной томографии, зачастую неспецифичны. В последнее время появились новые возможности методов радионуклидной диагностики в стратификации риска и оценке прогноза больных с амилоидозом сердца. В течение последних двух десятилетий разрабатывались различные классы радиофармпрепаратов на основе соединений, тропных к компонентам амилоидных инфильтратов. В данной работе описываются современные возможности и перспективы методов ядерной медицины при амилоидозе сердца, в том числе остеотропной и нейротропной сцинтиграфии, однофотонной и позитронной эмиссионной томографии.
1. Lachman H., Booth D., Booth S., et al . Misdiagnosis of hereditary amyloidosis as AL (primary) amyloidosis. N Engl J Med. 2002;346:1786-91. doi: 10.1001/archinte.166.17.1805.
2. Shah K.B., Inoue Y., Mehra M.R. Amyloidosis and the heart: a comprehensive review. Arch Intern Med. 2006;166(17):1805-13. doi: 10.1001/archinte.166.17.1805.
3. Chapter 65. The Dilated, Restrictive, and Infiltrative Cardiomyopathies. In: Mann D., Zipes D., Libby P., Bonow R. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. Saunders; 2015.
4. Blagova O.V., Nedostup A.V., Sedov V.P.,et al. Clinical masks of amyloidosis with the heart involment: modern diagnostic issues. Russian Journal of Cardiology. 2017;2(142):68-79. (In Russ.). doi: 10.15829/1560-4071-2017-2-68-79.
5. Zdanova E.A., Rameev V.V., Moiseev S.V., et al. Cardiac amyloidosis. Klinicheskaja Farmakologija i Terapija. 2011;20(5);44-50 (In Russ.).
6. Vrana J.A., Gamez J.D., Madden B.J., et all. Classification of amyloidosis by laser microdissection and mass spectrometry-based proteomic analysis in clinical biopsy specimens. Blood. 2009;114(24):4957-9. doi: 10.1182/blood-2009-07-230722.
7. Zhao L., Tian Z., Fang Q. Diagnostic accuracy of cardiovascular magnetic resonance for patients with suspected cardiac amyloidosis: a systematic review and meta-analysis. BMC Cardiovasc Disord. 2016;16:129. doi: 10.1186/s12872-016-0311-6.
8. Hazenberg B.P., van Rijswijk M.H., Piers D.A., et al. Diagnostic performance of 123I-labeled serum amyloid P component scintigraphy in patients with amyloidosis. Am J Med. 2006;119(4):e315-24. doi: 10.1016/j.amjmed.2005.08.043.
9. Perugini E., Guidalotti P.L., Salvi F., et al. Noninvasive etiologic diagnosis of cardiac amyloidosis using 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy. J Am Coll Cardiol. 2005;46(6):1076-84. doi: 10.1016/j.jacc.2005.05.073.
10. Rapezzi C., Quarta C.C., Guidalotti P.L., et al. Usefulness and limitations of 99mTc-3,3-diphosphono1,2-propanodicarboxylic acid scintigraphy in the aetiological diagnosis of amyloidotic cardiomyopathy. Eur J Nucl Med Mol Imaging. 2011;38(3):470-8. doi: 10.1007/s00259-010-1642-7.
11. Longhi S., Guidalotti P.L., Quarta C.C., et al. Identification of TTR-related subclinical amyloidosis with 99mTc-DPD scintigraphy. JACC Cardiovasc Imaging. 2014;7(5):531-2. doi: 10.1016/j.jcmg.2014.03.004.
12. Rapezzi C., Quarta C.C., Guidalotti P.L.,et al. Role of (99m)Tc-DPD scintigraphy in diagnosis and prognosis of hereditary transthyretin-related cardiac amyloidosis. JACC Cardiovasc Imaging. 2011;4(6):659-70. doi: 10.1016/j.jcmg.2011.03.016.
13. Hutt D.F., Quigley A.M., Page J., et al. Utility and limitations of 3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy in systemic amyloidosis. European Heart Journal Cardiovascular Imaging. 2014;15(11):1289-98. doi: 10.1093/ehjci/jeu107.
14. Glaudemans A.W.J.M., van Rheenen R.W.J., van den Berg M.P., et al. Bone scintigraphy with 99mtechnetiumhydroxymethylene diphosphonate allows early diagnosis of cardiac involvement in patients with transthyretin-derived systemic amyloidosis. Amyloid. 2014;21(1):35-44. doi: 10.3109/13506129.2013.871250.
15. Janssen S., Piers D.A., van Rijswijk M.H., et al. Soft-tissue uptake of 99mTc-diphosphonate and 99mTcpyrophosphate in amyloidosis. Eur J Nucl Med. 1990. 16(8-10): 663-670. doi: 10.1007/bf00998166.
16. Yamamoto Y., Onoguchi M., Haramoto M.,et al. Novel method for quantitative evaluation of cardiac amyloidosis using 201TlCl and 99mTc-PYP SPECT. Ann Nucl Med. 2012;26(8):634-43. doi: 10.1007/s12149-012-0627-y.
17. Bokhari S., Castano A., Pozniakoff T., et al. 99mTc-Pyrophosphate Scintigraphy for Differentiating Light-Chain Cardiac Amyloidosis From the Transthyretin-Related Familial and Senile Cardiac Amyloidoses. Circulation: Cardiovascular Imaging. 2013;6(2):195-201. doi: 10.1161/circimaging. 112.000132.
18. Glaudemans A.W.J.M., Slart R.H.J.A., Noordzij W., et al. Utility of 18F-FDG PET(/CT) in patients with systemic and localized amyloidosis. Eur J Nucl Med Mol Imaging. 2013;40(7):1095-101. doi: 10.1007/s00259-013-2375-1.
19. Antoni G., Lubberink M., Estrada S.,et al. In vivo visualization of amyloid deposits in the heart with 11C-PIB and PET. J Nucl Med. 2013;54(2):213-20. doi: 10.2967/jnumed.111.102053.
20. Dorbala S., Vangala D., Semer J., et al. Imaging cardiac amyloidosis: a pilot study using 18F-florbetapir positron emission tomography. Eur J Nucl Med Mol Imaging. 2014;41(9):1652-62.
21. Furukawa K., Ikeda S.i., Okamura N., et al. Cardiac Positron-Emission Tomography Images With an Amyloid-Specific Tracer in Familial Transthyretin-Related Systemic Amyloidosis. Circulation. 2012;125(3):556-7. doi: 10.1007/s00259-014-2787-6.
22. Falk R.H., Rubinow A., Cohen A.S. Cardiac arrhythmias in systemic amyloidosis: correlation with echocardiographic abnormalities. J Am Coll Cardiol. 1984;3(1):107-13. doi: 10.1016/s07351097(84)80436-2.
23. Sergienko V. B., Ansheles A. A. Radionuclide diagnosis neurotropic radiopharmaceuticals. Moscow: Infra-M; 2014. (In Russ.). 10.12737/1402.
24. Shvalev V. N., Reutov V. P., Sergienko V. B., et al. Mechanisms of development of cardiavascular diseases in age-related diorders of the nervous system. Kazanskij Medicinskij Zhurnal. 2016;97(4):598606. (In Russ.).
25. Lishmanov Yu.V., Yefimova, I.Yu., Chernov V.I., et al. Scintigraphy as a tool of diagnosis, prevention and monitoring of cardiac disease treatment. Sibirskij Medicinskij Zhurnal. 2007;22(3):74-7. (In Russ.).
26. Ansheles A. A., Shigoleva Ya. V., Sergienko I. V., Tereshchenko S. N. SPECT myocardial perfusion and sympathetic innervation in patients with hypertrophic cardiomyopathy. Kardiologicheskij Vestnik. 2016;XI(1):24-33. (In Russ.).
27. Ansheles A. A., Sergienko V.B. Standardization of 123I-meta-iodobenzyl guanidine cardiac neurotropic scintigraphy and single-photon emission tomography. Vestnik Rentgenologii i Radiologii. 2016;97(3):173-80. (In Russ.).
28. Jacobson A.F., Lombard J., Banerjee G., Camici P.G. 123I-MIBG Scintigraphy to predict risk for adverse cardiac outcomes in heart failure patients: Design of two prospective multicenter international trials. Journal of Nuclear Cardiology. 2009;16(1):113-21. doi: 10.1007/s12350-008-9008-2.
29. Sergienko V.B., Ansheles A.A. Radionuclide diagnosis in cardiology. In: Chazov E.I., ed. Manual of cardiology. Volume 1. Moscow: Praktika; 2014: 571-612. (In Russ.).
30. Ansheles A.A. Specific features of interpretation of myocardial perfusion single-photon emission computed tomography with computed tomographic absorption correction. Vestnik Rentgenologii i Radiologii. 2014;(2):5-20.(In Russ.).
31. Sasano T., Abraham M.R., Chang K.C.,et al. Abnormal sympathetic innervation of viable myocardium and the substrate of ventricular tachycardia after myocardial infarction. J Am Coll Cardiol. 2008;51(23):2266-75. doi: 10.1016/j.jacc.2008.02.062.
32. Sergienko V.B., Ansheles A.A. Tomographic methods in the assessment of myocardial perfusion. Vestnik Rentgenologii i Radiologii. 2010;(3):10-4. (In Russ.).
33. Ansheles A.A., Sergienko V.B. Tomographic Modalities in Myocardial Perfusion Assessment in Ischemic Heart Disease Patients. Radiacionnaja Onkologija i Jadernaja Medicina. 2011;(2):77-83. (In Russ.).__
34. Ansheles A.A., Martirosyan L.A., Sergienko I.V., Sergienko V.B. New approaches to quantifying early disorders and perfusion inhomogeneity of the myocardium according to the data of single-photon emission computed tomography. Vestnik Rentgenologii i Radiologii. 2015;(5):17-26. (In Russ.).
35. Ansheles A.A., Khalikova E.I., Ryzhikova O.A. New method of quantifying myocardial perfusion impairments assessed with single-photon emission computed tomography. Medical Physics. 2016;69(1):46-53. (In Russ.).
36. Dorbala S., Vangala D., Bruyere J., et al. Coronary Microvascular Dysfunction Is Related to Abnormalities in Myocardial Structure and Function in Cardiac Amyloidosis. JACC: Heart Failure. 2014;2(4):358-67. doi: 10.1016/j.jchf.2014.03.009.
37. Delahaye N., Dinanian S., Slama M.S., et al. Cardiac sympathetic denervation in familial amyloid polyneuropathy assessed by iodine-123 meta-iodobenzyl guanidine scintigraphy and heart rate variability. Eur J Nucl Med Mol Imaging. 1999;26(4):416-24. doi: 10.1007/s002590050406.
38. Delahaye N., Rouzet F., Sarda L., et al. Impact of Liver Transplantation on Cardiac Autonomic Denervation in Familial Amyloid Polyneuropathy. Medicine (Baltimore). 2006;85(4):229-38. doi: 10.1097/01.md.0000232559.22098.c3.
39. Haagsma E.B., Van Gameren I.I., Bijzet J., et al. Familial amyloidotic polyneuropathy: long-term followup of abdominal fat tissue aspirate in patients with and without liver transplantation. Amyloid. 2007;14(3):221-6. doi: 10.1080/13506120701461368.
40. Coutinho M.C.A., Cortez-Dias N., Cantinho G., et al. Reduced Myocardial 123-Iodine Meta-iodobenzyl guanidine Uptake: A Prognostic Marker in Familial Amyloid Polyneuropathy. Circulation: Cardiovascular Imaging. 2013;6(5):627-36. doi: 10.1161/circimaging.112.000367.
41. Hongo M., Urushibata K., Kai R., et al. Iodine-123 meta-iodobenzyl guanidine scintigraphic analysis of myocardial sympathetic innervation in patients with AL (primary) amyloidosis. Am Heart J. 2002;144(1):122-9.
42. Pankova A.N., Zavadovsky K.V.Estimation of Dysfunction of the Hearts's Right Ventricle at Patients with Pulmonary Embolizim by Scintigraphy. Medical Visualization. 2009;(3):24-30. (In Russ.).
43. Karamitsos T.D., Piechnik S.K., Banypersad S.M., et al. Noncontrast T1 Mapping for the Diagnosis of Cardiac Amyloidosis. JACC: Cardiovascular Imaging. 2013;6(4):488-97. doi: 10.1016/ j.jcmg.2012.11.013.
44. Di Silvestre D., Brambilla F., Mauri P.L. Multidimensional Protein Identification Technology for DirectTissue Proteomics of Heart. Methods Mol Biol. 2013;1005:25-38. doi: 10.1007/978-1-62703386-2_3.