СЕРДЕЧНО-СОСУДИСТЫЕ ЗАБОЛЕВАНИЯ И ЖИЗНЕННОЕ ИСТОЩЕНИЕ: ПРОСПЕКТИВНОЕ ИССЛЕДОВАНИЕ В РОССИИ/СИБИРИ (ПРОГРАММА ВОЗ МОНИКА — ПСИХОСОЦИАЛЬНАЯ)

V. Gafarov; M. Voevoda; E. Gromova; V. Maksimov; I. Gagulin; N. Yudin; A. Gafarova; T. Mishakova

Статья

СЕРДЕЧНО-СОСУДИСТЫЕ ЗАБОЛЕВАНИЯ И ЖИЗНЕННОЕ ИСТОЩЕНИЕ: ПРОСПЕКТИВНОЕ ИССЛЕДОВАНИЕ В РОССИИ/СИБИРИ (ПРОГРАММА ВОЗ МОНИКА — ПСИХОСОЦИАЛЬНАЯ)

V. Gafarov, M. Voevoda, E. Gromova, V. Maksimov, I. Gagulin, N. Yudin, A. Gafarova, T. Mishakova

2016

https://doi.org/10.15829/1560-4071-2016-4-eng-115-123

Цель. Исследовать распространенность жизненного истощения, его влияния на 14-летний риск развития сердечно-сосудистых заболеваний (ССЗ) (артериальной гипертонии (АГ), инфаркта миокарда (ИМ) и инсульта), а так же генетических особенностей жизненного истощения в открытой популяции среди мужчин 25-64 лет в России/Сибири (г.Новосибирск, мегаполис Западной Сибири).Материал и методы. Была обследована случайная репрезентативная выборка мужчин 25-64 лет в рамках программы ВОЗ “МONICA-психосоциальная (MOPSY)” в 1994г. Маастрихтский опросник (ОМ) использовался для оценки жизненного истощения. Генотипирование было выполнено для переменного числа тандемных повторов (VNTR) полиморфизмов генов DRD4 и DAT. Все новые случаи АГ, ИМ и инсульта были зарегистрированы у лиц без ССЗ в течение 14 лет (с 1994 по 2008гг). Статистический анализ проводился с помощью пакета программ SPSS 11.5. Кокс-пропорциональная регрессионная модель была использована для оценки риска развития (Hazard ratio — HR) с учетом временного интервала. Тест Х2 был использован для оценки статистической значимости различий между группами.Результаты. В исследованной популяции уровень жизненного истощения составил 66,8%. HR был значительно увеличен (АГ: HR=3,2; ИМ: HR=2,7; инсульт: HR=3,2) у мужчин с жизненным истощением, по сравнению с лицами без жизненного истощения в открытой популяции в течение первых пяти лет наблюдения. Многофакторное моделирование показало, что жизненное истощение вместе с сопутствующим социальным градиентом определяет развитие АГ, ИМ и инсульта в открытой популяции среди мужчин 25-64 лет. 7 аллель DRD4 и генотип 9/9 гена DAT были связаны с высоким уровнем жизненного истощения.Заключение. В открытой популяции среди мужчин 25-64 лет (Россия/ Сибирь, г.Новосибирск) определен высокий уровень жизненного истощения, как предиктор риска развития ССЗ. Жизненное истощение существенно связано с определенными VNTRr-полиморфизмами генов DRD4 и DAT.

Gafarov V., Voevoda M., Gromova E., Maksimov V., Gagulin I., Yudin N., Gafarova A., Mishakova T. СЕРДЕЧНО-СОСУДИСТЫЕ ЗАБОЛЕВАНИЯ И ЖИЗНЕННОЕ ИСТОЩЕНИЕ: ПРОСПЕКТИВНОЕ ИССЛЕДОВАНИЕ В РОССИИ/СИБИРИ (ПРОГРАММА ВОЗ МОНИКА — ПСИХОСОЦИАЛЬНАЯ). Российский кардиологический журнал. 2016;(4-eng):115-123. https://doi.org/10.15829/1560-4071-2016-4-eng-115-123

Цитирование

Список литературы

1. Appels A. Psychological prodromata of myocardial infarction and sudden death. Psychother Psychosom. 1980; 34:187–95.

2. Appels A, Otten F. Exhaustion as precursor of cardiac death. Br J Clin Psychol. 1992; 31: 351–6.

3. Appels A, Mulder P. Fatigue and heart disease. The association between ‘vital exhaustion’ and past, present and future coronary heart disease. J Psychosom Res. 1989; 33: 727–38.

4. Cole WR, Kawachi I, Sesso HD. Sense of exhaustion and coronary heart disease among college alumni. Am J Cardiol. 1999; 84: 1401–5.

5. Pignalberi C, Patti G, Chimenti C, et al. Role of different determinants of psychologival distress an acute coronary syndrome. J. Am. Coil. Cardiol. 1998;32(3): 613-9.

6. Prescott E, Holst C, Grønbaek M, et al. Vital exhaustion as a risk factor for ischaemic heart disease and all-cause mortality in a community sample. A prospective study of 4084 men and 5479 women in the Copenhagen City Heart Study. Int J Epidemiol. 2003; 32: 990–7.

7. Gafarov VV, Gagulin IV. Epidemiological approach to the study of psychosocial factors. Bulletin of Siberian Branch of the USSR Academy of Medical Sciences. 1993; 3: 77-81.

8. Gafarov VV, Pak VA, Gagulin IV, Gafarova AV. Epidemiology and prophylactics of chronic noncommunicable diseases during two decades and in the period of social-economic crisis in Russia (Publishing House of Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 2000) 282 p.

9. Bages N, Appels A, Falger PR. Vital exhaustion as a risk factor of myocardial infarction: a case-control study in Venezuela. Int J Behav Med. 1999; 6: 279-90.

10. Schuitemaker GE, Dinant GJ, van der Pol GA, Appels A. Assessment of vital exhaustion and identification of subjects at increased risk of myocardial infarction in general practice. Psychosomatics. 2004; 45: 414-8.

11. Schwartz SW, Carlucci C, Chambless LE, Rosamond WD. Synergism between smoking and vital exhaustion in the risk of ischemic stroke: evidence from the ARIC study. Ann Epidemiol. 2004; 14: 416-24.

12. Williams JE, Mosley TH Jr, Kop WJ, et al.. Vital exhaustion as a risk factor for adverse cardiac events (from the Atherosclerosis Risk In Communitiesstudy). Am J Cardiol. 2010; 15: 1661-5.

13. Chumaeva N, Hintsanen M, Ravaja N, et al. Chronic stress and the development of early atherosclerosis: Moderating effect of endothelial dysfunction and impaired arterial elasticity. Int J Envinron Res Public Health. 2009; 6: 2934–49.

14. Chumaeva N, Hintsanen M, Ravaja N, et al. Interactive effect of long-term mental stress and cardiac stress reactivity on carotid intima-media thickness: The Cardiovascular Risk in Young Finns study. Stress. 2009; 12: 283–93.

15. Schuitemaker GE, Dinant GJ, Van Der Pol GA, et al. Vital exhaustion as a risk indicator for first stroke. Psychosomatics. 2004; 45: 114-8.

16. Kornerup H, Marott JL, Schnohr P, et al. Vital exhaustion increases the risk of ischemic stroke in women but not in men: results from the Copenhagen City Heart Study. J Psychosom Res. 2010; 68: 131-7.

17. Elovainio M, Jokela M, Kivimäki M, et al. Genetic Variants in the DRD2 Gene Moderate the Relationship Between Stressful Life Events and Depressive Symptoms in Adults: Cardiovascular Risk in Young Finns Study. Psychosomatic Medicine. 2007; 69: 391-5.

18. Kivimäki M, Vahtera J, Elovainio M, et al. Death or illness of a family member, violence, interpersonal conflict, and financial difficulties as predictors of sickness absence: longitudinal cohort study on psychological and behavioral links. Psychosom Med. 2002; 64: 817–25.

19. Pani L, Porcella A, Gessa GL The role of stress in the pathophysiology of the dopaminergic system. Mol Psychiatry. 2000; 5: 14–21.

20. Paes de Sousa M, Tropa J. Evaluation of the efficacy of amineptine in a population of 1,229 depressed patients: results of a multicenter study carried out by 135 general practitioners. Clin Neuropharmacol. 1989;12: 77–86.

21. World Health Organization (1985). Proposal for the Multinational Monitoring of Trends in cardiovascular disease. Geneva.

22. World Health Organization (1988). MONICA Psychosocial Optional Study. Suggested Measurement Instruments. Copenhagen: WHO Regional Office for Europe.

23. Appels A, Mulder P. Excess fatigue as a precursor of myocardial infarction. Eur Heart J 1988; 9: 758-64.

24. Appels A, Mulder P. A questionnaire to assess premonitory symptoms of myocardial infarction. Int J Cardiol. 1988; 17: 15-24.

25. The WHO MONICA Project. A worldwide monitoring system for cardiovascular diseases: Cardiovascular mortality and risk factors in selected communities. World Health Stat A 1989; 27-149.

26. WHO MONICA Project prepared by Kuulasmaa K. et al. Baseline population survey data book. MONICA Memo 178 A. Helsinki, 1990

27. Tunstall-Pedoe H, editor. Prepared by Tunstall-Pedoe H, Kuulasmaa K, Tolonen H, Davidson M, Mendis S with 64 other contributors for The WHO MONICA Project. MONICA Monograph and Multimedia Sourcebook. Geneva: World Health Organization; 2003. ISBN 9241562234.

28. WHO MONICA Project prepared by Asplund K., et al. Stroke event registration quality report. MONICA Memo 212 A. — Helsinki. 1999.

29. Gafarov V.V., Gafarova A.V. Long-term trends and determinants of myocardial infarction morbidity, mortality, and lethality in Russian population. Internat.J.Med.and Med.Sci.— 2012; 2(11): 256-62.

30. Brien E. Blood pressure measuring devices: recommendations of the European Society of Hypertension. BMJ. 2001; 322: 531–36.

31. Lichter JB, Barr CL, Kennedy JL, et al. A hypervariable segment in the human dopamine receptor (DRD4) gene. Hum. Mol. Genet. 1993; 2:767-73.

32. Maniatis T, Fritsch EF, Sambrook J, Methods of genetic engineering. Molecular cloning (Trans. in Russian language) (Mir Publishing House, Moscow, 1984) 357 p.

33. Smith CL, Klco SR, Cantor CR. Pulsed Field Gel Electrophoresis and the Technology of Large DNA Molecules. In Davies K, editor. Genome Analysis: A Practical Approach. Translation from English. Moscow. Mir Publishers, 1990: 58-94.34. Nanko S, Hattori M, Ikeda K, Sasaki T, Kazamatsuri H, Kuwata S Dopamine D4 receptor polymorphism and schizophrenia. Lancet. 1993; 341: 689-90.

34. Glants С. Biomedical statistics. Translated from English. Moscow. 1998. Practika.

35. Cox D.R. Regression Models and Life Tables. Journal of the Royal Statistical Society Series B. 1972; 34: 187–220.

36. Nasledov AD, Mathematical approaches of psychological study. Analysis and data interpretation (St. Petersburg, 2004) 388 p.

37. Bühl A, Zöfel P. SPSS Version 11,5. Einführung in die moderne Datenanalyse unter Windows, 2005, 608 p.

38. Gafarov VV, Gromova EA, Kabanov YuN, Gagulin IV. Personality and its interaction with social environment: the road untrodden (Publishing House of Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 2008) 280 p.

39. Gromova H, Gafarov V, Gagulin I. Depression and risk of cardiovascular diseases among male aged 25-64 (WHO MONICA-psychosocial). J. Alaska Medicine. 2007: 2(49): 242-5.

40. Gafarov V, Gromova H, Gagulin I., et al. Arterial hypertension, myocardial infarction and stroke: risk of development and psychosocial factors. J. Alaska Medicine. 2007; 2(49): 114-6.

41. Gagulin IV, Gafarov AV, Gafarov VV, Pak VA. Breathes Vital Exhaustion And Its Relationship With Other Psychosocial Factors And Coronary Heart Disease. World оf Science, Culture, Education. 2010; 3 (22): 178-80.

42. Selye H. The stress of life. New York: McGraw-Hill, 1977. 515p.

43. Oganov RG, Kalinina AM, Maslennikova GY, Koltunov IE, Prerequisites of prophylactics of cardiovascular diseases in the Russian Federation. Cardiovascular Therapy and Prophylactics. 2010; 6:4-9.

44. Ayvazyan TA, Psychorelaxation in the treatment of hypertension. Cardiology. 1991; 31: 95-8.

45. Marrkovitz JH, Matthews KA, Kannel WB Psychological predictors of hypertension in the Framingham study. Is there tension in hypertension in the tension in hypertension? J.A.M.A., 1993; 270: 2439-43.

46. Gafarov VV, Gromova EA, Gagulin IV, Pilipenko PI The study of risk for development of myocardial infarction according to WHO MONICA-Psychosocial program. The Journal of Neurology and Psychiatry n.a. S.S. Korsakova. Stroke. Supplement. 2005; 13: 36-41.

47. Gafarov VV, Gromova EA, Gagulin IV, Gafarova AV. Study of myocardial infarction risk factors within the framework of the WHO Monica-psychosocial program. Klin Med (Mosk). 2006; 84(6): 24-6.

48. Gafarov VV, Gromova EA, Gafarova AV, et al. Vital exhaustion in open population of 25–64-year-old men (epidemiological study based on WHO MONICA-Psychosocial program). Bulletin of Siberian Medicine. 2009; 1:(2)(8), 19-22.

49. Alfimova MV, Golimbet VE, Genes and neurophysiological indicators of cognitive processes: overview of the studies. Journal of Higher Nervous Activity n.a. I.P. Pavlov. 2011; 61: 389-401.

50. Korsten P, Mueller JC, Hermannstädter C, et al. Association between DRD4 gene polymorphism and personality variation in great tits: a test across four wild populations. Mol Ecol. 2010; 19: 832-43.

51. Cloninger CR A systematic method for clinical description and classification of personality variants: A proposal. Arch. Gen. Psychiatry. 1987; 44: 573–88.

52. Cloninger CR, Svrakic DM Integrative psychobiological approach to psychiatric assessment and treatment. Psychiatry. 1997. 60: 120–41.

53. Cloninger CR, Zohar AH Personality and the perception of health and happiness. J Affect Disord. 2011; 128: 24-32.

54. Greenwood TA, Schork NJ, Eskin E, Kelsoe JR. Identification of additional variants within the human dopamine transporter gene provides further evidence for an association with bipolar disorder in two independent samples. Mol. Psychiatry. 2006; 11: 125-33.

55. Mazei-Robison MS, Couch RS, Shelton RC, et al. Sequence variation in the human dopamine transporter gene in children with attention deficit hyperactivity disorder Neuropharmacology. 2005.; 49: 724-36.

56. Gafarov V, Voevoda M, Gromova E, et al. Genetic markers for trait anxiety as the risk factors for cardiovascular diseases (WHO-MONICA Program and MONICA-Psychosocial Subprogram). International Journal of Medicine and Medical Sciences. 2012; 2(12): 284-9.

57. Korsten P, Mueller JC, Hermannstädter C, et al. Association between DRD4 gene polymorphism and personality variation in great tits: a test across four wild populations . Mol Ecol. 2010; 19: 832-43.

58. Matthews LJ, Butler PM Novelty-seeking DRD4 polymorphisms are associated with human migration distance out-of-Africa after controlling for neutral population gene structure. Am J Phys Anthropol. 2011; 145: 382-9.

59. Ray LA, Bryan A, Mackillop J, et al. The dopamine D Receptor (DRD4) gene exon III polymorphism, problematic alcohol use and novelty seeking: direct and mediated genetic effects .Addict Biol. 2009; 14: 238-44.

60. Vandenbergh DJ, Persico AM, Hawkins AL, et al. Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR. Genomics. 1992:14: 1104-6.

61. Gelernter J, Kranzler HR, Satel SL, Rao PA. Genetic association between dopamine transporter protein alleles and cocaine-induced paranoia. Neuropsychopharmacology. 1994; 11: 195-200.

62. Gianaros PJ, Manuck SB. Neurobiological Pathways Linking Socioeconomic Position and Health. Psychosom Med. 2010; 72: 450–61.

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V. Gafarov НИИ терапии и профилактической медицины
M. Voevoda НИИ терапии и профилактической медицины
E. Gromova НИИ терапии и профилактической медицины
V. Maksimov НИИ терапии и профилактической медицины
I. Gagulin НИИ терапии и профилактической медицины
N. Yudin НИИ терапии и профилактической медицины
A. Gafarova НИИ терапии и профилактической медицины
T. Mishakova НИИ терапии и профилактической медицины

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Российский кардиологический журнал

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