Статья
Кардиометаболический синдром: насколько важна в реальной клинической практике активация PPARг-рецепторов?
Резюме Взаимодействие генетических и внешнесредовых факторов, метаболических и сосудистых нарушений увеличивает риск общей смертности, почечной дисфункции и кардиоваскулярных осложнений. Инсулинорезистентность играет ключевую роль в развитии метаболического синдрома. Установлена четкая связь между активностью ренин-ангиотензин-альдостероновой системы (РААС) и метаболическими факторами сердечно-сосудистого риска. Интенсивно изучается роль рецепторов, активируемых пролифератором пероксисом г (PPARг), в жировом и углеводном обмене. Влияние тиазолидиндионов на кардиоваскулярный прогноз у пациентов с метаболическим синдромом имеет противоречивый характер и требует дальнейшего изучения. Плейотропные эффекты средств-блокаторов РААС играют важную роль в лечении больных высокого сердечно-сосудистого риска. Наличие у телмисартана уникальных свойств частичного агониста PPARг-рецепторов расширяет перспективы рациональной фармакотерапии артериальной гипертензии у пациентов с кардиометаболическим синдромом.
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