Статья
ЛЕКАРСТВЕННЫЕ ВЗАИМОДЕЙСТВИЯ НОВЫХ ПЕРОРАЛЬНЫХ АНТИКОАГУЛЯНТОВ: ВНУТРИ И ВНЕ ЯЧЕЕК ТАБЛИЦЫ
В некоторых отечественных публикациях высказывается мнение о том, что ривароксабан обладает наиболее благоприятным профилем лекарственного взаимодействия по сравнению с другими новыми оральными антикоагулянтами (НОАК). Основой для подобных суждений стала сводная таблица лекарственных взаимодействий НОАК из рекомендаций Европейской ассоциации сердечного ритма 2015 г. по применению НОАК у пациентов с неклапанной фибрилляцией предсердий.В настоящей работе обсуждаются содержащиеся в таблице некорректные качественные формулировки и несоответствующие первоисточникам количественные данные о лекарственных взаимодействиях НОАК, а также приводятся уточненные и дополненные сведения об изменениях плазменных концентраций НОАК при совместном приеме с препаратами других групп. На основе представленных данных авторы приходят к заключению о том, что по профилю лекарственного взаимодействия ривароксабан существенно не отличается от других НОАК.
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