Статья
НЕАЛКОГОЛЬНАЯ ЖИРОВАЯ БОЛЕЗНЬ ПЕЧЕНИ И СЕРДЕЧНО-СОСУДИСТЫЙ РИСК: СОСТОЯНИЕ ПРОБЛЕМЫ
Неалкогольная жировая болезнь печени (НАЖБП) – самое распространенное заболевание печени в мире, особенно часто встречающееся у больных с атеросклерозом или его осложнениями (инфаркт миокарда, инсульт). Впоследствии было выявлено, что НАЖБП повышает сердечно-сосудистый риск вне зависимости от традиционных факторов риска. Возможными механизмами повышения сердечно-сосудистого риска, индуцированного НАЖБП, служат оксидативный стресс, субклиническое воспаление, инсулинорезистентность, эндотелиальная дисфункция и нарушение секреции адипоцитокинов. Такие факторы риска, как артериальная гипертензия, дислипидемия, ожирение, сахарный диабет 2 типа часто сосуществуют с НАЖБП, способствуя повышению сердечно-сосудистого риска у этих пациентов. Таким образом, с большой долей вероятности НАЖБП можно рассматривать как дополнительный фактор риска сердечно-сосудистых заболеваний. В статье подробно рассмотрены механизмы, индуцированные НАЖБП, которые повышают сердечно-сосудистый риск независимо от традиционных факторов риска.
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