Статья
СНИЖЕНИЕ СЕРДЕЧНО-СОСУДИСТЫХ ОСЛОЖНЕНИЙ СОВРЕМЕННОЙ САХАРОСНИЖАЮЩЕЙ ТЕРАПИИ САХАРНОГО ДИАБЕТА 2 ТИПА: «ФЛОРЕНТИЙСКАЯ ЕРЕСЬ»
Классические гипогликемические препараты включают бигуаниды, препараты сульфонилмочевины, меглитиниды, глитазоны и ингибиторы альфа-глюкозидазы. Современный алгоритм гипогликемической терапии на первой ступени предполагает изменение образа жизни и монотерапию метформином, на второй ступени — комбинированную терапию. Однако влияние комбинаций сахароснижающих препаратов на долгосрочный сердечно-сосудистый прогноз у пациентов с сахарным диабетом 2 типа изучено недостаточно. Комбинированная терапия глибенкламидом и метформином может иметь неблагоприятные сердечно-сосудистые эффекты, в связи с чем необходимо избегать длительного ее применения у пациентов с коронарной болезнью сердца и разработать адекватные фармакологические подходы к коррекции гипергликемии.
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