Статья
ЗНАЧЕНИЕ ФАРМАКОГЕНЕТИЧЕСКОГО ТЕСТИРОВАНИЯ ПО CYP2C19 ДЛЯ ПЕРСОНАЛИЗАЦИИ ПРИМЕНЕНИЯ АНТИАГРЕГАНТОВ В КАРДИОЛОГИЧЕСКОЙ ПРАКТИКЕ
Рассматривают клиническое значение генетического полиморфизма CYP2C19, ассоциированного с нарушением образования активного метаболита клопидогрела, для эффективности и безопасности данного препарата у пациентов кардиологического профиля. Обсуждают тактику выбора антиагрегантов по результатам фармакогенетического тестирования пациентов по CYP2C19, а также показания для применения подобного подхода в клинической практике, что должно повысить эффективность и безопасность лечения.
1. Klingenberg M. Pigments of liver microsomes. Arch Biochem Biophys 1958;75:376-86.
2. Garfinkel D. Studies on pig liver microsomes. Enzymes and pigment composition of different micro- somal fractions. Arch Biochem Biophys 1958;77:493-509.
3. Evans WE, McLeod HL. Pharmacogenomics--drug disposition, drug targets, and side effects. N Engl J Med 2003;348(6):538-49.
4. Goldstein, J. A. Clinical relevance of genetic polymorphisms in the human CYP2C subfamily. Br J Clin Pharmacol 2001;52: 349-55.
5. Steg PG, James SK, Atar D, et al. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J 2012; 33(20): 2569-619.
6. Hamm CW, Bassand JP, Agewall S, et al. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J 2011; 32(23): 2999-3054.
7. Yusuf S, Zhao F., Mehta SR, et al. The Clopidogrel in Unstable Angina to Prevent Recurrent Events Tri- al Investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 2001;345:494-502.
8. Chen ZM, Jiang LX, Chen YP, et al. COMMIT (ClOpidogrel and Metoprolol in Myocardial Infarction Trial) collaborative group. Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial in- farction: randomised placebo-controlled trial. Lancet 2005;366:1607-21.
9. Isaacs D, Lander C, McNeil J, et al. Clopidogrel – haemorrhage and haematological disorders. Aust Adv Drug Reactions Bull 2004; 23(4): 14-5.
10. Sabatine MS, Cannon CP, Gibson CM, et al. Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation. N Engl J Med 2005;352(12):1179-89.
11. Mega JL, Close SL, Wiviott SD, et al. Cytochrome P-450 polymorphisms and response to clopidogrel. N Engl J Med 2009;360(4):354-62.
12. Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, et al. Contribution of gene sequence variations of the hepatic cytochrome P450 3A4 enzyme to variability in individual responsiveness to clopidogrel. Ar- terioscler Thromb Vasc Biol 2006; 26(8):1895-900.
13. Taubert D, von Beckerath N, Grimberg G, et al. Impact of P-glycoprotein on clopidogrel absorption. Clin Pharmacol Ther 2006; 80(5):486-501.
14. Simon T, Verstuyft C, Mary-Krause M, et al Genetic determinants of response to clopidogrel and cardiovascular events. N Engl J Med 2009; 360(4):363-375.
15. Weiss EJ, Bray PF, Tayback M, et al. A Polymorphism of a Platelet Glycoprotein Receptor as an Inherited Risk Factor for Coronary Thrombosis. N Engl J Med 1996; 334:1090-1094.
16. Trenk D, Hochholzer W, Fromm MF, et al. Cytochrome P450 2C19 681G >A polymorphism and high on-clopidogrel platelet reactivity associated with adverse 1-year clinical outcome of elective percu- taneous coronary intervention with drug-eluting or bare-metal stents. J Am Coll Cardiol 2008; 51:1925-34.
17. Shuldiner AR, O'Connell JR, GurbelPA et al. Influence of CYP2C19 polymorphism on antiplatelet effects of clopidogrel and long-term recurrent ischemic event occurrence. JAMA 2009; 302:849-58.
18. Sibbing D, Stegherr J, Latz W, et al. Cytochrome P450 2C19 loss-of-function polymorphism and stent thrombosis following percutaneous coronary intervention. Eur Heart J 2009; 30 (8): 916-22.
19. Mega JL, Simon T, Collet JP et al. Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis. JAMA 2010;304(16):1821-30.
20. Holmes MV, Perel P, Shah T et al. CYP2C19 genotype, clopidogrel metabolism, platelet function, and cardiovascular events: a systematic review and meta-analysis. JAMA 2011;306(24):2704-14.
21. Steg PG, James SK, Atar D, et al. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J 2012; 33(20): 2569-19.
22. FDA Drug Safety Communication: reduced effectiveness of Plavix (clopidogrel) in patients who are poor metabolizers of the drug. Available at: http://www.fda.gov/Drugs/DrugSafety/ Postmarket- DrugSafetyInformationforPatientsandProviders/ucm203888.htm. Date of access 12.08.2013.
23. Levine GN, Bates ER, Blankenship JC, et al. ACCF /AHA/SCAI Guideline for Percutaneous Coronary Intervention. JACC 2011; 58(24):44-122.
24. Komarov LA, Panchenko EP, AE Donnikov and other factors that determine the clinical efficacy of clopi- dogrel and prognosis of patients with stable coronary heart disease. Cardiology 2011, (2): 8-18. Russian (Комаров Л.А., Панченко Е.П., Донников А.Е. и др. Факторы, определяющие клиническую эффективность клопидогрела и прогноз больных со стабильной формой ишемической болезни сердца. Кардиология 2011; (2): 8-18).
25. Galyavich AS, Valeyeva DD, Minnetdinov R.Sh. and other CYP2C19 gene polymorphism in patients with myocardial infarction who use clopidogrel. Cardiology 2012, (4): 20-4. Russian (Галявич А.С, Валеева Д.Д., Миннетдинов Р.Ш. и др. Полиморфизм гена CYP2C19 у больных инфарктом миокарда, применяющих клопидогрел. Кардиология 2012; (4): 20-4).
26. Kudzoeva ZF, Boqueria, LA, La Boqueria, OL Pharmacogenetic testing ispolzovnaiem modern techniques in patients taking clopidogrel, as a basis of personalized medicine. Proceedings of the annual session of the XVII Scientific Center of Cardiovascular Surgery. AN Bakuleva. Moscow 2013: 111. Russian (Кудзоева З.Ф., Бокерия Л.А., Бокерия О.Л. Фармакогенетическое тестирование с использованием современных методик у пациентов, принимающих клопидогрель, как основа персонализированной медицины. Материалы XVII ежегодной сессии научного центра сердечнососудистой хирургии им. А.Н. Бакулева. Москва 2013: 111).
27. Bonello L, Camoin-Jau L, Arques L et al. Adjusted clopidogrel loading doses according to vasodila- tor-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance: a multicenter randomized prospective study. J Am Coll Cardiol2008;51:1404-1411
28. Mega J, Close SL, Wiviott SD et al. Cytochrome P450 genetic polymorphisms and the response to prasugrel: relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes. Circulation 2009;119:2553-60.
29. Gurbel PA, Bliden KP, Butler K et al. Response to ticagrelor in clopidogrel nonresponders and responders and effect of switching therapies: the RESPOND study. Circulation 2010; 121:1188-99.
30. Jeong YH, Lee SW, Choi BR et al. Randomized comparison of adjunctive cilostazol versus high maintenance dose clopidogrel in patients with high post-treatment platelet reactivity: results of the ACCEL-RESISTANCE (Adjunctive Cilostazol Versus High Maintenance Dose Clopidogrel in Patients With Clopidogrel Resistance) randomized study. J Am Coll Cardiol 2009;53:1101-09.
31. Von Beckerath N, Taubert D, Pogatsa-Murray G et al. Absorption, metabolization, and antiplatelet ef- fects of 300-, 600-, and 900-mg loading doses of clopidogrel: results of the ISAR-CHOICE (Intra- coronary Stenting and Antithrombotic Regimen: Choose Between 3 High Oral Doses for Immediate Clopidogrel Effect) trial. Circulation 2005;112:2946-50.
32. Gladding P, Webster M, Zeng I et al. The antiplatelet effect of higher loading and maintenance dose regimens of clopidogrel: the PRINC (Plavix Response in Coronary Intervention) trial. JACC Cardiovasc Interv 2008; 1:612-9.
33. Aleil B, L. Jacquemin L, De Poli F et al. Clopidogrel 150 mg/day to overcome low responsiveness in patients undergoing elective percutaneous coronary intervention: results from the VASP-02 (Vasodilator-Stimulated Phosphoprotein-02) randomized study. JACC Cardiovasc Interv 2008;1:631-8.
34. Price MJ. Berger PB, Teirstein PS, et al. Standardvs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trial. JAMA 2011;305(11):1097-105.
35. Reese ES, Mullins CD, Beitelshees AL, et al. Cost-Effectiveness of Cytochrome P450 2C19 Genotype Screening for Selection of Antiplatelet Therapy with Clopidogrel or Prasugrel. Pharmacotherapy 2012;32(4):323-32.
36. Sibbing D, Koch W, Gebhard D, et al. Cytochrome 2C19*17 Allelic Variant, Platelet Aggregation, Bleeding Events, and Stent Thrombosis in Clopidogrel-Treated Patients With Coronary Stent Placement. Cir- culation 2010;121(4):512-8.