Статья
Кардиоваскулярные эффекты метформина
Сахарный диабет 2 типа является одним из важнейших независимых факторов риска развития, прогрессирования и смертности от сердечно-сосудистых заболеваний (ССЗ). Перед мировыми сообществами встает вопрос о разработке оптимальной тактики ведения больных с данной коморбидностью. Так, назначаемый препарат должен оказывать не только адекватный гипогликемический эффект, но и обладать рядом кардиопротективных свойств, быть безопасным у больных ССЗ и, возможно, улучшать прогноз и снижать показатели смертности. Настоящий обзор посвящен представителю класса бигуанидов – метформину, являющемуся одним из самых первых и наиболее эффективных гипогликемических препаратов как в качестве монотерапии, так и в комбинации с другими препаратами данной группы и инсулином, в то время как доказательная база в отношении его сердечно-сосудистого профиля только набирает обороты. Таким образом, цель настоящего обзора – описать кардиоваскулярные эффекты метформина в контексте последних исследований.
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