Статья
Длина теломер и сердечно-сосудистые заболевания
Известно, что в течение жизни у людей происходит укорочение длины теломерных участков хромосом, ограничивающих количество делений клеток, которые имеют свой предел (предел Хейфлика). Считается, что эволюционно этот феномен является компромиссом для предотвращения риска развития рака. В то же время в современном обществе, в котором продолжительность жизни значительно возросла, укорочение теломерных участков хромосом может играть важную роль в развитии заболеваний, связанных со старением, и в первую очередь с такой группой патологий, как сердечно-сосудистые заболевания, являющиеся в 35% случаев причиной смерти в пожилом возрасте. В обзоре представлена информация, посвященная исследованиям, направленным на определение роли длины теломер в риске развития сердечно-сосудистых заболеваний и описание факторов, оказывающих влияние на изменение длины теломерных участков хромосом, а также возможных причин формирования геномной нестабильности вследствие повреждения теломерных участков хромосом.
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