Статья
Патогенетические аспекты взаимосвязи инсульта и нарушений дыхания во сне
Обзор посвящен патофизиологическим основам взаимосвязи острого нарушения мозгового кровообращения (ОНМК) и нарушений дыхания во сне. Наряду с основными механизмами реализации патологического действия апноэ во сне на сердечно-сосудистую систему, такими как интермиттирующая гипоксемия, нарушение структуры сна и колебания внутригрудного давления, нарушение симпатико-парасимпатического баланса, оксидативный стресс, рассматриваются генетические факторы и роль глимфатической системы. В обзоре представлены данные о влиянии нарушений дыхания во сне на развитие различных подтипов ОНМК по классификации TOAST и так называемого «инсульта пробуждения», а также потенциальные механизмы, через которые повреждение головного мозга может способствовать возникновению апноэ во сне или усугублению уже имеющихся нарушений.
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