Статья
Ауторегуляция мозгового кровотока в норме и при патологии
Метаболические потребности головного мозга (ГМ) в значительной степени зависят от интенсивности функционирования различных его отделов, что требует постоянной регуляции уровня местного кровотока. Важность точной и своевременной регуляции мозгового кровотока усиливается отсутствием запасов субстратов для автономного получения энергии в нервной ткани. При этом состояние системной гемодинамики может оказывать значительное влияние на органный кровоток. В то же время, учитывая роль центральной нервной системы в обеспечении всех физиологических процессов, регуляция органного мозгового кровотока направлена на минимизацию возможных неблагоприятных последствий влияния нарушений системной гемодинамики. В связи с этим регуляция мозгового кровотока основана на множественных и сложных физиологических механизмах, реализующихся на различных уровнях. Базовым уровнем регуляции мозгового кровотока является миогенная реакция, которая обеспечивает феномен ауторегуляции кровотока в ГМ. В настоящем обзоре будут рассмотрены физиологические механизмы, лежащие в основе миогенной регуляции, а также изменение этой регуляции при различных заболеваниях
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