Статья
Терапевтическая гипотермия при остром инфаркте миокарда
В обзоре представлена основная информация о влиянии терапевтической гипотермии на ишемизированный миокард, проведен анализ результатов экспериментальных и клинических работ по испытанию терапевтической гипотермии при инфаркте миокарда. Обсуждены результаты сравнения общей гипотермии тела и локальной гипотермии миокарда. Намечены пути дальнейших исследований этой технологии при инфаркте миокарда.
1. Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med. 2002;346(8):549-56. doi:10.1056/NEJMoa012689.
2. Bernard SA, Gray TW, Buist MD, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med. 2002;346(8):557-63. doi:10.1056/NEJMoa003289.
3. Therapeutic Hypothermia After Cardiac Arrest. An Advisory Statement by the Advanced Life Support Task Force of the International Liaison Committee on Resuscitation. Circulation. 2003;108:118-21. doi:10.1161/01.CIR.0000079019.02601.90.
4. Dae MW, Gao DW, Sessler DI, et al. Effect of endovascular cooling on myocardial temperature, infarct size, and cardiac output in human-sized pigs. Am J Physiol Heart Circ Physiol. 2002;282(5):H1584-91. doi:10.1152/ajpheart.00980.2001.
5. Duncker DJ, Klassen CL, Ishibashi Y, et al. Effect of temperature on myocardial infarction in swine. Am J Physiol. 1996;270(4 Pt 2):H1189-99. doi:10.1152/ajpheart.1996.270.4.H1189.
6. Hale SL, Dave RH, Kloner RA. Regional hypothermia reduces myocardial necrosis even when instituted after the onset of ischemia. Basic Res Cardiol. 1997;92(5):351-7. doi:10.1007/BF00788947.
7. Hale SL, Kloner RA. Ischemic preconditioning and myocardial hypothermia in rabbits with prolonged coronary artery occlusion. Am J Physiol. 1999;276(6):H2029-34. doi:10.1152/ajpheart.1999.276.6.H2029.
8. Herring MJ, Dai W, Hale SL, et al. Rapid Induction of Hypothermia by the ThermoSuit System Profoundly Reduces Infarct Size and Anatomic Zone of No Reflow Following Ischemia-Reperfusion in Rabbit and Rat Hearts. J Cardiovasc Pharmacol Ther. 2015;20(2):193-202. doi:10.1177/1074248414535664.
9. Dai W, Hale S, Kloner RA. Delayed therapeutic hypothermia protects against the myocardial no-reflow phenomenon independently of myocardial infarct size in a rat ischemia/ reperfusion model. Int J Cardiol. 2017;236:400-4. doi:10.1016/j.ijcard.2017.01.079.
10. Shi J, Dai W, Kloner RA. Therapeutic Hypothermia Reduces the Inflammatory Response Following Ischemia/Reperfusion Injury in Rat Hearts. Ther Hypothermia Temp Manag. 2017;7(3):162-70. doi:10.1089/ther.2016.0042.
11. Simkhovich BZ, Hale SL, Kloner RA. Metabolic mechanism by which mild regional hypothermia preserves ischemic tissue. J Cardiovasc Pharmacol Ther. 2004;9(2):83-90. doi:10.1177/107424840400900203.
12. Huang CH, Chiang CY, Pen RH, et al. Hypothermia treatment preserves mitochondrial integrity and viability of cardiomyocytes after ischaemic reperfusion injury. Injury. 2015;46(2):233-9. doi:10.1016/j.injury.2014.10.055.
13. Götberg M, Olivecrona GK, Engblom H, et al. Rapid short-duration hypothermia with cold saline and endovascular cooling before reperfusion reduces microvascular obstruction and myocardial infarct size. BMC Cardiovasc Disord. 2008;8:7. doi:10.1186/1471-2261-8-7.
14. Maeng M, Mortensen UM, Kristensen J, et al. Hypothermia during reperfusion does not reduce myocardial infarct size in pigs. Basic Res Cardiol. 2006;101(1):61-8. doi:10.1007/s00395-005-0550-7.
15. Lim K, Yang JH, Hahn JY, et al. Impact of Natural Mild Hypothermia in the Early Phase of ST-Elevation Myocardial Infarction: Cardiac Magnetic Resonance Imaging Study. J Cardiovasc Imaging. 2018;26(3):175-85. doi:10.4250/jcvi.2018.26.e21.
16. Testori C, Beitzke D, Mangold A, et al. Out-of-hospital initiation of hypothermia in ST-segment elevation myocardial infarction: a randomised trial. Heart. 2019;105(7):531-7. doi:10.1136/heartjnl-2018-313705.
17. Nichol G, Strickland W, Shavelle D, et al.; VELOCITY Investigators. Prospective, multicenter, randomized, controlled pilot trial of peritoneal hypothermia in patients with ST-segmentelevation myocardial infarction. Circ Cardiovasc Interv. 2015;8(3):e001965. doi:10.1161/CIRCINTERVENTIONS.114.001965.
18. Dixon SR, Whitbourn RJ, Dae MW, et al. Induction of mild systemic hypothermia with endovascular cooling during primary percutaneous coronary intervention for acute myocardial infarction. J Am Coll Cardiol. 2002;40(11):1928-34. doi:10.1016/s0735-1097(02)02567-6.
19. Erlinge D, Götberg M, Lang I, et al. Rapid endovascular catheter core cooling combined with cold saline as an adjunct to percutaneous coronary intervention for the treatment of acute myocardial infarction. The CHILL-MI trial: a randomized controlled study of the use of central venous catheter core cooling combined with cold saline as an adjunct to percutaneous coronary intervention for the treatment of acute myocardial infarction. J Am Coll Cardiol. 2014;63(18):1857-65. doi:10.1016/j.jacc.2013.12.027.
20. Noc M, Erlinge D, Neskovic AN, et al. COOL AMI EU pilot trial: a multicentre, prospective, randomised controlled trial to assess cooling as an adjunctive therapy to percutaneous intervention in patients with acute myocardial infarction. EuroIntervention. 2017;13(5):e531-e539. doi:10.4244/EIJ-D-17-00279.
21. Dallan LAP, Giannetti NS, Rochitte CE, et al. Cooling as an Adjunctive Therapy to Percutaneous Intervention in Acute Myocardial Infarction: COOL-MI InCor Trial. Ther Hypothermia Temp Manag. 2021;11(3):135-44. doi:10.1089/ther.2020.0018.
22. Otterspoor LC, van Nunen LX, van ‘t Veer M, et al. Intracoronary Hypothermia Before Reperfusion to Reduce Reperfusion Injury in Acute Myocardial Infarction: A Novel Hypothesis and Technique. Ther Hypothermia Temp Manag. 2017;7(4):199-205. doi:10.1089/ther.2017.0006.
23. Götberg M, Olivecrona GK, Koul S, et al. A pilot study of rapid cooling by cold saline and endovascular cooling before reperfusion in patients with ST-elevation myocardial infarction. Circ Cardiovasc Interv. 2010;3(5):400-7. doi:10.1161/CIRCINTERVENTIONS.110.957902.
24. Kim H, Lee J, Song W, et al. Feasibility and safety of regional myocardial hypothermia during myocardial ischemia and infarction in pigs. Coron Artery Dis. 2005;16(2):125-9. doi:10.1097/00019501-200503000-00008.
25. Otake H, Shite J, Paredes OL, et al. Catheter-based transcoronary myocardial hypothermia attenuates arrhythmia and myocardial necrosis in pigs with acute myocardial infarction. J Am Coll Cardiol. 2007;49(2):250-60. doi:10.1016/j.jacc.2006.06.080.
26. Otterspoor LC, van ‘t Veer M, Van Nunen LX, et al. Safety and feasibility of selective intracoronary hypothermia in acute myocardial infarction. EuroIntervention. 2017;13(12):e1475-e1482. doi:10.4244/EIJ-D-17-00240.
27. Wang YS, Zhang J, Li YF, et al. A pilot clinical study of adjunctive therapy with selective intracoronary hypothermia in patients with ST-segment elevation myocardial infarction. Catheter Cardiovasc Interv. 2018;92(7):E433-E440. doi:10.1002/ccd.27864.
28. El Farissi M, Keulards DCJ, van ‘t Veer M, et al. Selective intracoronary hypothermia in patients with ST-elevation myocardial infarction. Rationale and design of the EURO-ICE trial. EuroIntervention. 2021;16(17):1444-6. doi:10.4244/EIJ-D-19-00471.
29. El Farissi M, Good R, Engstrøm T, et al. Safety of Selective Intracoronary Hypothermia During Primary Percutaneous Coronary Intervention in Patients With Anterior STEMI. JACC Cardiovasc Interv. 2021;14(18):2047-55. doi:10.1016/j.jcin.2021.06.009.