Статья
ИНСУЛИН И ЛЕПТИН: СПОРНЫЕ И НЕРЕШЕННЫЕ ВОПРОСЫ ИХ ВЗАИМОДЕЙСТВИЯ
Лептин и его рецептор широко распространены главным образом в белой жировой ткани. Концентрация лептина в сыворотке крови коррелирует с индексом массы тела и снижается при голодании. Инсулин, по-видимому, увеличивает экспрессию мРНК и белка лептина, а также его высвобождение адипоцитами, причем синтезированного как предварительно, так и de novo, и снижает уровень адипонектина и его рецепторов. Согласно литературным данным, хроническая гиперинсулинемия повышает содержание лептина. В настоящем обзоре обобщены последние знания о влиянии инсулина на синтез и секрецию лептина, представлены клеточные механизмы, контролирующие его синтез и высвобождение белой жировой тканью.
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