Статья
Провоспалительные адипокины и цитокины при абдоминальном ожирении как фактор развития атеросклероза и патологии почек
В последние десятилетия наблюдается рост распространенности избыточной массы тела и ожирения. Ожирение стало недооцененной пандемией и угрозой общественному здоровью во всем мире. Жировая ткань позиционируется как эндокринный орган, секретирующий широкий спектр провоспалительных цитокинов и адипокинов, индуцируя состояние хронического субвоспаления. Результаты эпидемиологических исследований за последние 30 лет показали также, что висцеральная жировая ткань является независимым фактором риска развития атеросклероза, кардиометаболических заболеваний и хронической болезни почек. Нами выполнен систематический обзор с целью обобщить важные аспекты состояния хронического субвоспаления в контексте его влияния на снижение скорости клубочковой фильтрации и развитие хронической болезни почек. В обзоре рассмотрены вопросы этиологии и патогенеза ожирения, гормонального профиля жировой ткани, молекулярных механизмов воздействия провоспалительных цитокинов и адипокинов на почки и патофизиологии почечных заболеваний. Использованы сведения по теме из публикаций на основе базы данных Pubmed.
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