Статья
Фундаментальные и прикладные аспекты кальцификации коронарных артерий
В обзорной статье обобщены результаты зарубежных и отечественных исследований, посвященных механизмам развития, а также клинико-прогностической роли коронарной кальцификации при ишемической болезни сердца. Представлены современные взгляды кардиологов, хирургов и врачей общей практики в отношении коморбидных заболеваний, проявлением которых может быть коронарная кальцификация. Обозначены современные аспекты формирования связи между атерогенезом, коронарной кальцификацией и резорбцией костной ткани; выделены группы информативных биологических маркеров, способных отражать тяжесть остео-коронарного континуума. Освещены современные диагностические возможности для выявления и характеристики коронарной кальцификации, обозначены их достоинства и ограничения. Обсуждены перспективы фармакологической коррекции атеросклероза с позиции влияния на коронарный кальциноз и остеопенический синдром. Представлены дальнейшие перспективы и направления исследований в этой области медицинской науки.
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