Статья
Вазоактивные факторы в патогенезе преэклампсии
На сегодня ни одна проблема в акушерстве не вызывает столь пристального внимания как проблема преэклампсии и эклампсии. В общей популяции беременных женщин частота преэклампсии составляет 5-10 %, а эклампсии 0,05 %. В мировой литературе ежегодно публикуется более 1500 научных работ, посвященных различным аспектам этиологии, патогенеза, профилактики и лечения этого осложнения беременности, но многие вопросы так и остаются далекими от разрешения. На сегодняшний день нет единой теории этиологии и патогенеза преэклампсии, что в значительной степени затрудняет своевременную диагностику, оценку степени тяжести и проведение профилактических мероприятий. Данный обзор посвящен изучению роли эндогенных вазоактивных факторов в патогенезе гестационной гипертензии. Кроме того, детально рассмотрена роль эндогенных дигиталисоподобных ингибиторов Na/K-AТФазы (маринобуфагенин) в патогенезе преэклампсии.
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