Статья
РОЛЬ ГЛИКОПРОТЕИНА-Р В РАЦИОНАЛЬНОЙ ФАРМАКОТЕРАПИИ В КАРДИОЛОГИИ
На основе анализа данных литературы показана роль гликопротеина-P, белка-транспортера, в рациональной фармакотерапии в кардиологии на примере его субстратов – дигоксина, антитромбоцитарных препаратов и антикоагулянтов. Определение полиморфизма C3435T гена множественной лекарственной устойчивости (MDR1), кодирующего гликопротеин-Р, при проведении фармакотерапии дигоксином, антитромбоцитарными препаратами (клопидогрелом, тикагрелолом, прасугрелом) и антикоагулянтами (дабигатрана этексилатом, ривароксабаном, эдоксабаном) не является целесообразным в рутинной практике. Клиническое значение для эффективности и безопасности фармакотерапии имеют межлекарственные взаимодействия при совместном назначении указанных лекарственных средств с субстратами, индукторами и ингибиторами гликопротеина-P.
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