Статья
ЭТИОЛОГИЯ, ПАТОГЕНЕЗ И ПРОФИЛАКТИКА СПАЕЧНОГО ПРОЦЕССА
В обзоре представлена актуальная тема, связанная с риском образования спаек в послеоперационном периоде. Рассмотрены и описаны аспекты патогенеза спаечного процесса, а также связанных с ним факторов риска, освещены методы профилактики. Отдельно отмечен метод электроспиннинга, позволяющий создавать противоспаечные барьеры на основе биодеградируемых полимеров с добавлением лекарственного вещества, что является перспективным направлением в создании мембран для предотвращения спаечного процесса.
1. Бокерия Л.А., Гудкова Р.Г. Сердечно-сосудистая хирургия – 2015. Болезни и врожденные аномалии системы кровообращения. М.: НЦССХ им А.Н. Бакулева; 2016. 208с. Bokeriya L.A., Gudkova R.G. Serdechnososudistaya khirurgiya – 2015. Bolezni i vrozhdennye anomalii sistemy krovoobrashcheniya. M.: NTsSSKh im A.N. Bakuleva; 2016..
2. Бокерия Л.А., Сивцев В.С. Послеоперационный спаечный перикардит: фактры риска, патогенез и методы профилактики. Анналы хирургии . 2014; 6: 7-15. Bokeriya L.A., Sivtsev V.S. Posleoperatsionnyy spaechnyy perikardit: faktry riska, patogenez i metody profilaktiki. Annaly khirurgii. 2014; 6: 7-15..
3. Marelli A.J., Mackie A.S., Ionescu-Ittu R., Rahme E., Pilote L. Congenital heart disease in the general population: changing prevalence and age distribution. Circulation. 2007; 115: 163-164. doi:10.1161/CIRCULATIONAHA.106.627224
4. Ellman P.I., Smith R.L., Girotti M.E., Thompson P.W., Kron I.L. Cardiac injury during resternotomy does not affect perioperative mortality. Journal of the American College of Surgeons. 2008; 206: 993–997. doi.10.1016/j.jamcollsurg.2007.12.010
5. Elahi M., Dhannapuneni R., Firmin R., Hickey M. Direct complications of repeat median sternotomy in adults. Asian Cardiovasc Thorac Ann. 2005; 13: 135-137. doi: 10.1177/021849230501300208
6. Roselli E.E., Pettersson G.B., Blackstone E.H., Brizzio M.E., Houghtaling P.L., Lauck R., et al. Adverse events during reoperative cardiac surgery: Frequency, characterization, and rescue. J. Thorac. Cardiovasc. Surg. 2008; 135: 316–323. doi.org/10.1016/j.jtcvs.2007.08.060
7. Park C.B., Suri R.M., Burkhart H.M., et al. Identifying patients at particular risk of injury during repeat sternotomy: analysis of 2555 cardiac reoperations. J. Thorac. Cardiovasc. Surg.. 2010; 140(5): 1028–1035 doi.org/10.1016/j.jtcvs.2010.07.086
8. Cannata A., Petrella D., Bruschi G., Fratto P., Gambacorta M., Martinelli L. Postsurgical intrapericardial adhesions: mechanisms of formation and prevention. Ann. Thorac. Surg. 2013; 95(5): 1818–1826. doi.org/10.1016/j.athoracsur.2012.11.020
9. Бритиков Д.В., Бокерия Л.А., Бокерия О.Л., Новикова С.П., Cалохединова Р.Р., Городков А.Ю. и др. Биологические пленочные имплантаты для профилактики спаечного процесса (экспериментальное исследование). Бюллетень НЦССХ ИМ. А.Н. Бакулева РАМН Сердечно-сосудитые заболевания. 2016;17 (3):13 Britikov D.V., Bokeriya L.A., Bokeriya O.L., Novikova S. P., Calokhedinova R.R., Gorodkov A. Yu. Et al. Biologicheskie plenochnye implantaty dlya profilaktiki spaechnogo protsessa (eksperimental’noe issledovanie). Byulleten’ NTsSSKh IM. A.N. Bakuleva RAMN Serdechnososuditye zabolevaniya. 2016;17 (3):13.
10. Бокерия Л.А. Беришвили И.И. Хирургическая анатомия сердца. М.; 2006. Bokeriya L.A. Berishvili I.I. Khirurgicheskaya anatomiya serdtsa. Moscow; 2006..
11. Herrick S.E., Mutsaers S.E. The potential of mesothelial cells intissue engineering and regenerative medicine applications. Int. J. Artif. Organs. 2007; 30: 527—540.
12. Lucas P.A. Stem cells for mesothelial repair: an understudied modality. Int. J. Artif .Organs. 2007; 30: 550—556.
13. Mutsaers S.E., Peрle C.M., Lansley S.M., Herrick S.E. The origin of regenerating mesothelium: a historical perspective. Int. J. Artif. Organs. 2007; 30 (6): 484–494.
14. Nkere U.U., Whawell S.A., Sarraf C.E., et al. Perioperative histologic and ultrastructural changes in the pericardium and adhesions. Ann. Thorac. Surg. 1994; 58 437–444. doi: 10.1016/0003-4975(94)92224-1
15. Leak L.V., Ferrans V.J., Cohen S.R., Eidbo E.E., Jones M. Animal model of acute pericarditis and its progression to pericardial fibrosis and adhesions: ultrastructural studies. Am. J. Anat. 1987; 180:373–390. doi:10.1002/aja.1001800408
16. Holmdahl L. The role of fibrinolysis in adhesion formation. Eur J. Surg. 1997; l: 24—31. doi: 10.1046/j.1524-475X.1994.20306.x
17. DiZerega G.S., Campeau J.D. Peritoneal repair and post-surgical adhesion formation. Hum Reprod Update. 2001; 7: 547—555. doi:10.1093/humupd/7.6.547
18. Herrick S.E., Mutsaers S.E., Ozua P., Sulaiman H., Omer A., Boulos P. et al. Human peritoneal adhesions are highly cellular, innervated, and vascularized. J. Pathol. 2000; 192: 67—72: doi 10.1002/1096-9896
19. Sulaiman H., Gabella G., Davis C., Mutsaers S.E., Boulos P., Laurent G.J. et al. Growth of nerve fibres into murine peritoneal adhesions. J. Pathol. 2000;192: 396—403. doi: 10.1002/1096-9896(2000)9999:99993.0.CO;2-4
20. Sulaiman H., Gabella G., Davis M.C., Mutsaers S.E., Boulos P., Laurent G.J. et al. Presence and distribution of sensory nerve fibers in human peritoneal adhesions. Ann Surg. 2001; 234: 256—261. doi: 10.1097/00000658-200108000-00016
21. Chandler W., Velan T. Secretion of tissue plasminogen activator and plasminogen activator inhibitor-1 during cardiopulmonary bypass. Thromb. Res. 2003; 112 (3): 185–92 doi:10.1016/j.thromres.2003.11.006
22. Malouf J.F., Alam S., Gharzeddine W., Stefadouros M.A. The role of anticoagulation in the development of pericardial effusion and late tamponade after cardiac surgery. Eur. Heart J. 1994; 15 (4): 583–4. doi: 10.1093/eurheartj/14.11.1451
23. Quin J.A., Tauriainen M.P., Huber L.M., McIntire D.D., Kaiser P.A., Ring W.S. et al. Predictors of pericardial effusion after orthotopic heart transplantation. J. Thorac. Cardiovasc. Surg. 2002; 124 (5): 979–83. doi:10.1067/mtc.2002.124387
24. Ананьев Д.А. Клошинских А. А. Способ изоляции сердца от задней поверхности грудины. Патент RU 2503418. 2012 04 декабря. Anan’ev D.A. Kloshinskih A. A. Sposob izoljacii serdca ot zadnej poverhnosti grudiny. Patent RU 2503418. 2012 04 december.
25. Белов Ю.В. Искусство коронарной хирургии. M.: МИА; 2009. Belov Ju.V. Iskusstvo koronarnoj hirurgii. Moscow; 2009
26. Свободов А.А., Зеленикин М.А., Свободов А.А. Способ безопасной рестернотомии. Грудная и сердечно-сосудистая хирургия. 2008; 1: 66–67 Svobodov A.A., Zelenikin M.A., Svobodov A.A. Sposob bezopasnoj resternotomii. Grudnaja i serdechno-sosudistaja hirurgija. 2008; 1: 66–67..
27. Quarti A., Nardone S., Colaneri M., Santoro G., Pozzi M. Preliminary experience in the use of an extracellular matrix to repair congenital heart diseases. I. Cardiovasc. Thorac. Surg. 2011; 13: 569–572 doi: 10.1510/icvts.2011.280016.
28. Badylak S.F., Freytes D.O., Gilbert T.W. Extracellular matrix as a biological scaffold material: structure and function. Acta Biomater. 2009; 5 (1): 1–13. doi: 10.1016/j.actbio.2008.09.013
29. Boyd W.D., Johnson W.E. 3rd, Sultan P.K., Deering T.F., Matheny R.G. Pericardial reconstruction using an extracellular matrix implant correlates with reduced risk of postoperative atrial fibrillation in coronary artery bypass surgery patients. Heart Surg. Forum. 2010; 13: 311–6. doi: 10.1532/HSF98.20091184.
30. Gerdisch M.W., Shea R.J., Barron M. D. Clinical experience with CorMatrix extracellular matrix in the surgical treatment of mitral valve disease. J. Thorac. Cardiovasc. Surg. 2014; 148(4): 1370–1378. doi: 10.1016/j.jtcvs.2013.10.055.
31. Napoleone C., Valori A., Crupi G., et al. An observational study of Coseal for the prevention of adhesions in pediatric cardiac surgery . I. Cardiovasc. Thorac. Surg. 2009; 9: 978–982 doi: 10.1510/icvts.2009.212175.
32. Cannata A., Petrella D., Gambacorta M. , Russo C.F , Bruschi G., Martinelli L . Histological findings following use of Coseal in a patient with a left ventricular assist device. Surg. Innov. 2013; 20(6): 35-7. doi: 0.1177/1553350612443899
33. Konertz W.F., Kostelka M., Mohr F.W., et al. Reducing the incidence and severity of pericardial adhesions with a sprayable polymeric matrix . Ann Thorac. Surg. 2003;(76): 1270–1274 doi: 10.1016/S0003-4975(03)00733-
34. Salminen J.T, Mattila I., Puntila J.T., Sairanen H.I. Prevention of postoperative pericardial adhesions in children with hypoplastic left heart syndrome. I. Cardiovasc. Thorac. Surg. 2011;12:270–272 doi: 10.1510/icvts.2010.241448
35. Haensig M., Mohr F.W., Rastan A.J. Bioresorbable adhesion barrier for reducing the severity of postoperative cardiac adhesions: focus on REPEL-CV . Med Devices (Auckl). 2011;4: 17–25 doi: 10.2147/MDER.S7957
36. Schreiber C., Boening A., Kostolny M., et al. European clinical experience with REPEL-CV. Expert Rev Med Devices. 2007; 4 : 291–295 doi: 10.1586/17434440.4.3.291
37. Pines E. A comparative, evaluator-blinded, randomized, parallel study to determine the safety and effectiveness of REPEL-CV® for reducing post-operative adhesions following pediatric cardiothoracic surgery. Med Devices. 2011; 4: 17–25. doi: 10.2147/MDER.S7957
38. Schreiber C., Boening A., Kostolny M., et al. European clinical experience with REPEL-CV. Expert. Rev. Med. Devices. 2007; 4: 291–295. doi: 10.1586/17434440.4.3.291
39. Lodge A.J., Wells W.J., Backer C.L. et al. A novel bioresorbable film reduces postoperative adhesions after infant cardiac surgery. Ann. Thorac. Surg. 2008; 86(2): 614–21 doi: 10.1016/j.athoracsur.2008.04.103.
40. Beck D.E., Cohen Z., Fleshman J.W., et al. A prospective, randomized, multicenter, controlled study of the safety of Seprafilm adhesion barrier in abdominopelvic surgery of the intestine . Dis. Colon. Rectum. 2003; 46: 1310–1319. doi: 10.1097/01.DCR.0000089117.62296.E4
41. Diamond M.P., Burns E.L., Accomando B., Mian S., Holmdahl L. Seprafilm adhesion barrier: a review of preclinical, animal, and human investigational studies . Gynecol. Surg . 2012; 9: 237–245 doi: 10.1007/s10397-012-0741-9
42. Iliopoulos J., Cornwall G.B., Evans R.O., et al. Evaluation of a bioabsorable polylactide film in a large animal model for the reduction of retrosternal adhesions . J. Surg. Res. 2004; 118: 144–153. doi: 10.1016/j.jss.2003.10.023
43. Bel A., Kachatryan L., Bruneval P., et al. A new absorbable collagen membrane to reduce adhesions in cardiac surgery . I. Cardiovasc. Thorac. Surg . 2010; 10: 213–216. doi: 10.1510/icvts.2009.215251
44. Bel A., Ricci M., Piquet J., et al. Prevention of postcardiopulmonary bypass pericardial adhesions by a new resorbable collagen membrane . I. Cardiovasc. Thorac. Surg . 2012; 14: 469–473. doi: 10.1093/icvts/ivr159
45. Zhou J., Liwski R.S., Elson C., Lee T.D. Reduction in postsurgical adhesion formation after cardiac surgery in a rabbit model using N,O carboxymethyl chitosan to block cell adherence. J. Thorac. Cardiovasc. Surg. 2008; 135(4): 777-783
46. Gabbay S., Guindy A.M., Andrews J.F., Amato J.J., Seaver P., Khan M.Y. New outlook on pericardial substitution after open heart operations. Ann. Thorac. Surg.1989; ( 48): 803-812. doi:10.1016/0003-4975(89)90674-7
47. Seeger J.M., Kaelin L.D., Staples E.M., Yaacobi Y., Bailey J.C., Normann S., Burns J.W., Goldberg E.P. Prevention of postoperative pericardial adhesions using tissue-protective solutions. J. Surg. Res. 1997; 68 (1): 63-66. doi: 10.1006/jsre.1996.4990
48. Pacholewicz J.K., Daloisio C., Shawarby O.A., Dharan S.M., Gu J., McGrath L.B. Efficacy of autologous peritoneum as a biological membrane in cardiac surgery. J. Cardiothorac Surg. 1994; 8: 563–565. doi: 10.1016/1010-7940(94)90077-9
49. Chang Y., Lai Po-H., Wang Ch.-Ch., et al. Mesothelium regeneration on acellular bovine pericardia loaded with an angiogenic agent (ginsenoside Rg1) successfully reduces postsurgical pericardial adhesions J. Thorac. Cardiovasc. Surg. 2006;132: 867-874. doi: 10.1016/j.jtcvs.2006.06.029
50. Sakuma K., Iguchi A., Ikada Y., Tabayashi K. Closure of the pericardium using synthetic bioabsorbable polymers. Ann. Thorac. Surg. 2005; 80:1835-1840. doi: 10.1016/j.athoracsur.2005.04.078
51. Насонова М.В., Ходыревская Ю.И., Бураго А.Ю., Доронина Н.В., Ежов В.А., Кудрявцева Ю.А. Противовоспалительные биодеградируемые мембраны для профилактики образования послеоперационных спаек. Сибирский медицинский журнал. 2014; 8: 54-59. doi. 10.1234/XXXXXXXX-2014-8-54-59 Nasonova M.V., Hodyrevskaja Ju.I., Burago A.Ju., Doronina N.V., Ezhov V.A., Kudrjavceva Ju.A. Protivovospalitel’nye biodegradiruemye membrany dlja profilaktiki obrazovanija posleoperacionnyh spaek. Sibirskij medicinskij zhurnal. 2014; 8.