Статья
Статины и их антиаритмическая активность
Клинические испытания используемых в настоящее время антиаритмических препаратов нередко свидетельствуют об их неэффективности при развитии жизнеугрожающих желудочковых аритмий и внезапной коронарной смерти (ВКС), а также о недостаточном фармакологическом контроле фибрилляции предсердий (ФП). Статины обладают помимо холестерин-снижающего действия рядом плейотропных эффектов (противовоспалительный, антипролиферативный, улучшение эндотелиальной функции и т.п.). Они способны снизить риск развития жизнеугрожающих аритмий и ВКС у больных острым инфарктом миокарда, перенесших коронарную реваскуляризацию и с наличием имплантированного кардиовертера-дефибриллятора. Терапия статинами способна уменьшить риск возникновения рецидивов ФП.
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