Статья
Двойное ингибирование холестерина — новый подход к эффективному контролю гиперлипидемии и атеросклероза
Повышение уровня холестерина липопротеринов низкой плотности (ХС ЛНП) — один из основных факторов риска (ФР) ишемической болезни сердца и атеросклероза. Статины, имея убедительную доказательную базу по снижению смертности, являются основными препаратами для лечения больных с атеросклерозом. Результаты контролируемых исследований последних лет по снижению ХС послужили обоснованием для снижения уровня целевых значений липидов: ХС ЛНП ≤ 2 ммоль/л. Двойное ингибирование ХС — новая концепция в снижении ХС плазмы крови до 50% за счет блокирования синтеза (статин) и уменьшения реабсорбции пищевого и билиарного ХС в тонком кишечнике. Клинические исследования препарата Инеджи® с фиксированной комбинацией (эзетимиб/симвастатин) показали высокую эффективность в достижении новых целевых уровней ХС ЛНП, а также хорошую переносимость и безопасность по сравнению с монотерапией статинами. Текущее клиническое исследование IMPROVE—IT с оценкой влияния двойного ингибирования на сердечно-сосудистую смертность позволит окончательно определить место эзетимиба и Инеджи® в лечении больных с дислипидемиями и атеросклерозом.
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