Статья
Профилактика сердечно-сосудистых заболеваний на протяжении жизни. Часть 1: преконцепционный, пренатальный и грудной периоды
Известные на данный момент профилактические вмешательства позволяют предотвратить или значимо отсрочить бóльшую часть сердечно-сосудистых заболеваний (ССЗ). Разнообразные факторы – внутренние биологические, психологические, влияние внешней окружающей среды – взаимосвязаны между собой и воздействуют на человека на протяжении всей его жизни, определяя вероятность развития ССЗ. Это свидетельствует о необходимости профилактических мер на всех жизненных этапах и даже до рождения. Положительные эффекты профилактики реализуются посредством различных молекулярных механизмов на генетическом, эпигенетическом и метаболическом уровнях. В связи с тем, что многие факторы риска ССЗ имеют накопительный эффект, внедрение превентивных мер, начиная с самых ранних этапов развития человека, будет иметь наибольшую эффективность. В статье рассмотрены различные аспекты профилактики ССЗ в преконцепционном, пренатальном и грудном периодах.
1. Piepoli MF, Hoes AW, Agewall S, et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Eur Heart J. 2016;37(29):2315-2381. doi:10.1093/eurheartj/ehw106.
2. BБойцов С.А., Оганов Р.Г. Четверть века в поисках оптимальных путей профилактики неинфекционных заболеваний и новые задачи на будущее (к 25-летнему юбилею образования Государственного научно-исследовательского центра профилактической медицины). Профилактическая медицина. 2013;16(5):3-8.
3. Бойцов СА. Механизмы снижения смертности от ишемической болезни сердца в разных странах мира. Профилактическая медицина. 2013;16(5):9-19.
4. Beal MA, Yauk CL, Marchetti F. From sperm to offspring: Assessing the heritable genetic consequences of paternal smoking and potential public health impacts. Mutat Res - Rev Mutat Res. 2017;773:26-50. doi:10.1016/j.mrrev.2017.04.001.
5. Saliba A, Figueiredo ACV, Baroneza JE, et al. Genetic and genomics in congenital heart disease: a clinical review. J Pediatr (Rio J). 2019;96(3):279-288. doi:10.1016/j.jped.2019.07.004.
6. Hanson M. The inheritance of cardiovascular disease risk. Acta Paediatr Int J Paediatr. 2019;108(10):1747-1756. doi:10.1111/apa.14813.
7. Dendale P, Scherrenberg M, Sivakova O, Frederix I. Prevention: From the cradle to the grave and beyond. Eur J Prev Cardiol. 2019;26(5):507-511. doi:10.1177/2047487318821772.
8. Daiber A, Lelieveld J, Steven S, et al. The “exposome” concept-how environmental risk factors influence cardiovascular health. Acta Biochim Pol. 2019;66(3):269-283. doi:10.18388/abp.2019_2853.
9. Vermeulen R, Schymanski EL, Barabási AL, Miller GW. The exposome and health: Where chemistry meets biology. Science (80- ). 2020;367(6476):392-396. doi:10.1126/science.aay3164.
10. Li H, Kilgallen AB, Münzel T, et al. Influence of mental stress and environmental toxins on circadian clocks: Implications for redox regulation of the heart and cardioprotection. Br J Pharmacol. February 2020:bph.14949. doi:10.1111/bph.14949.
11. Engel GL. The clinical application of the biopsychosocial model. Am J Psychiatry. 1980;137(5):535-544. doi:10.1176/ajp.137.5.535.
12. Constitution of the World Health Organization. Конституция Всемирной организации здравоохранения. https://www.who.int/ru/about/who-we-are/constitution (03 July 2020)
13. Rodríguez-Rodríguez P, Ramiro-Cortijo D, Reyes-Hernández CG, López de Pablo AL, Carmen González M, Arribas SM. Implication of oxidative stress in fetal programming of cardiovascular disease. Front Physiol. 2018;9(MAY). doi:10.3389/fphys.2018.00602.
14. McCue K, DeNicola N. Environmental Exposures in Reproductive Health. Obstet Gynecol Clin North Am. 2019;46(3):455-468. doi:10.1016/j.ogc.2019.04.005.
15. Segal TR, Giudice LC. Before the beginning: environmental exposures and reproductive and obstetrical outcomes. Fertil Steril. 2019;112(4):613-621. doi:10.1016/j.fertnstert.2019.08.001.
16. Corchia C, Mastroiacovo P. Health promotion for children, mothers and families: Here’s why we should “think about it before conception.” Ital J Pediatr. 2013;39(1):68. doi:10.1186/1824-7288-39-68.
17. Marczylo EL, Amoako AA, Konje JC, Gant TW, Marczylo TH. Smoking induces differential miRNA expression in human spermatozoa: a potential transgenerational epigenetic concern? Epigenetics. 2012;7(5):432-439. doi:10.4161/epi.19794.
18. Denham J. Exercise and epigenetic inheritance of disease risk. Acta Physiol. 2018;222(1). doi:10.1111/apha.12881.
19. Yu Z, Han S, Zhu J, Sun X, Ji C, Guo X. Pre-Pregnancy Body Mass Index in Relation to Infant Birth Weight and Offspring Overweight/Obesity: A Systematic Review and Meta-Analysis. PLoS One. 2013;8(4). doi:10.1371/journal.pone.0061627.
20. McPherson NO, Owens JA, Fullston T, Lane M. Preconception diet or exercise intervention in obese fathers normalizes sperm microRNA profile and metabolic syndrome in female offspring. Am J Physiol - Endocrinol Metab. 2015;308(9):E805-E821. doi:10.1152/ajpendo.00013.2015.
21. Carrier screening in the age of genomic medicine. Obstet Gynecol. 2017;129(3):e35-e40. doi:10.1097/AOG.0000000000001951.
22. Antonarakis SE. Carrier screening for recessive disorders. Nat Rev Genet. 2019;20(9):549-561. doi:10.1038/s41576-019-0134-2.
23. Novak CM, Graham EM. Obstetric management, tests, and technologies that impact childhood development. Dev Med Child Neurol. 2019;61(9):1002-1007. doi:10.1111/dmcn.14160.
24. van Gelder MMHJ, de Jong-van den Berg LTW, Roeleveld N. Drugs associated with teratogenic mechanisms. Part II: a literature review of the evidence on human risks. Hum Reprod. 2014;29(1):168-183. doi:10.1093/humrep/det370.
25. Hall E, Panepinto R, Bowman EK. Preconception Care for the Patient and Family. Nurs Clin North Am. 2018;53(2):169-176. doi:10.1016/j.cnur.2018.01.012.
26. O’Brien AP, Hurley J, Linsley P, McNeil KA, Fletcher R, Aitken JR. Men’s Preconception Health: A Primary Health-Care Viewpoint. Am J Mens Health. 2018;12(5):1575-1581. doi:10.1177/1557988318776513.
27. Singhal V. Pregnancy. In: Essentials of Neuroanesthesia. Elsevier; 2017:669-680. doi:10.1016/B978-0-12-805299-0.00040-3.
28. Ramos DE. Preconception Health: Changing the Paradigm on Well-woman Health. Obstet Gynecol Clin North Am. 2019;46(3):399-408. doi:10.1016/j.ogc.2019.04.001.
29. Arabin B, Baschat AA. Pregnancy: An Underutilized Window of Opportunity to Improve Long-term Maternal and Infant Health-An Appeal for Continuous Family Care and Interdisciplinary Communication. Front Pediatr. 2017;5:69. doi:10.3389/fped.2017.00069.
30. Crispi F, Miranda J, Gratacós E. Long-term cardiovascular consequences of fetal growth restriction: biology, clinical implications, and opportunities for prevention of adult disease. Am J Obstet Gynecol. 2018;218(2):S869-S879. doi:10.1016/j.ajog.2017.12.012.
31. Barker DJ. A new model for the origins of chronic disease. Med Health Care Philos. 2001;4(1):31-35. doi:10.1023/A:1009934412988.
32. Stupin JH, Arabin B. Overweight and obesity before, during and after pregnancy. Geburtshilfe Frauenheilkd. 2014;74(7):639-645. doi:10.1055/s-0034-1368486.
33. Leybovitz-Haleluya N, Wainstock T, Landau D, Sheiner E. Maternal smoking during pregnancy and the risk of pediatric cardiovascular diseases of the offspring: A population-based cohort study with up to 18-years of follow up. Reprod Toxicol. 2018;78:69-74. doi:10.1016/j.reprotox.2018.03.009.
34. Nanda S, Savvidou M, Syngelaki A, Akolekar R, Nicolaides KH. Prediction of gestational diabetes mellitus by maternal factors and biomarkers at 11 to 13 weeks. Prenat Diagn. 2011;31(2):135-141. doi:10.1002/pd.2636.
35. Hinman SK, Smith KB, Quillen DM, Smith MS. Exercise in Pregnancy: A Clinical Review. Sports Health. 2015;7(6):527-531. doi:10.1177/1941738115599358.
36. Gaillard R, Felix JF, Duijts L, Jaddoe VWV. Childhood consequences of maternal obesity and excessive weight gain during pregnancy. Acta Obstet Gynecol Scand. 2014;93(11):1085-1089. doi:10.1111/aogs.12506.
37. Bommarito PA, Martin E, Fry RC. Effects of prenatal exposure to endocrine disruptors and toxic metals on the fetal epigenome. Epigenomics. 2017;9(3):333-350. doi:10.2217/epi-2016-0112.
38. Gore AC, Chappell VA, Fenton SE, et al. EDC-2: The Endocrine Society’s Second Scientific Statement on Endocrine-Disrupting Chemicals. Endocr Rev. 2015;36(6):E1-E150. doi:10.1210/er.2015-1010.
39. Madhloum N, Janssen BG, Martens DS, et al. Cord plasma insulin and in utero exposure to ambient air pollution. Environ Int. 2017;105:126-132. doi:10.1016/j.envint.2017.05.012.
40. Corno G, Espinoza M, Maria Baños R. A narrative review of positive psychology interventions for women during the perinatal period. J Obstet Gynaecol (Lahore). 2019;39(7):889-895. doi:10.1080/01443615.2019.1581735.
41. Cheng ER, McGough H, Tucker Edmonds B. Paternal preferences, perspectives, and involvement in perinatal decision making. Obstet Gynecol Surv. 2019;74(3):170-177. doi:10.1097/OGX.0000000000000650.
42. Agosti M, Tandoi F, Morlacchi L, Bossi A. Nutritional and metabolic programming during the first thousand days of life. Pediatr Med Chir. 2017;39(2):157. doi:10.4081/pmc.2017.157.
43. Canani RB, Di Costanzo M, Leone L, et al. Epigenetic mechanisms elicited by nutrition in early life. Nutr Res Rev. 2011;24(2):198-205. doi:10.1017/S0954422411000102.
44. Peters SAE, Van Der Schouw YT, Wood AM, et al. Parity, breastfeeding and risk of coronary heart disease: A pan-European case-cohort study. Eur J Prev Cardiol. 2016;23(16):1755-1765. doi:10.1177/2047487316658571.
45. Agostoni C, Decsi T, Fewtrell M, et al. Complementary feeding: A commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2008;46(1):99-110. doi:10.1097/01.mpg.0000304464.60788.bd.
46. Clark MM, Hildreth A, Batalov S, et al. Diagnosis of genetic diseases in seriously ill children by rapid whole-genome sequencing and automated phenotyping and interpretation. Sci Transl Med. 2019;11(489). doi:10.1126/scitranslmed.aat6177.
47. Dron JS, Hegele RA. The evolution of genetic-based risk scores for lipids and cardiovascular disease. Curr Opin Lipidol. 2019;30(2):71-81. doi:10.1097/MOL.0000000000000576.
48. Ceyhan-Birsoy O, Ceyhan-Birsoy O, Murry JB, et al. Interpretation of Genomic Sequencing Results in Healthy and Ill Newborns: Results from the BabySeq Project. Am J Hum Genet. 2019;104(1):76-93. doi:10.1016/j.ajhg.2018.11.016.
49. Brummelte S, Galea LAM. Postpartum depression: Etiology, treatment and consequences for maternal care. Horm Behav. 2016;77:153-166. doi:10.1016/j.yhbeh.2015.08.008.
50. Murphy MO, Cohn DM, Loria AS. Developmental origins of cardiovascular disease: Impact of early life stress in humans and rodents. Neurosci Biobehav Rev. 2017;74(Pt B):453-465. doi:10.1016/j.neubiorev.2016.07.018.