Статья
Показатели жесткости аорты при дегенеративном аортальном стенозе
Аортальный стеноз (АС) является одним из наиболее распространенных сердечно-сосудистых заболеваний. Распространенность АС и сосудистая жесткость ассоциированы с возрастом. Повышенная артериальная жесткость является независимым фактором риска сердечно-сосудистых событий. Патогенетические и клинические взаимосвязи дегенеративного АС и жесткости аорты мало изучены. В настоящем обзоре отражены современные представления о взаимосвязях дегенеративного АС и аортальной ригидности. Описаны результаты исследований о влиянии хирургической и эндоваскулярной коррекции порока на показатели жесткости аорты. Обсуждены возможности их использования для прогноза течения АС и исходов протезирования клапана. Определены нерешенные вопросы и направления дальнейших исследований в этой области.
1. Вицлеб Э. Функции сосудистой системы. В кн.: Физиология человека. Под ред. Р. Шмидт, Г. Тевс. М.: Мир, 2005. С. 498–566.
2. Кобалава Ж. Д., Котовская Ю. В., Виллевальде С. В., Соловьева А. Е., Амирбегишвили И. М. Артериальная жесткость и хроническая болезнь почек: причины и последствия. Рациональная фармакотерапия в кардиологии. 2014;10(1):83–91.
3. Васюк Ю. А., Иванова С. В., Школьник Е. Л., Котовская Ю. В., Милягин В.А., Олейников В.Э. и др. Согласованное мнение российских экспертов по оценке артериальной жесткости в клинической практике. Кардиоваскулярная терапия и профилактика. 2016;15(2):4–19.
4. Милягин В. А., Комиссаров В. Б. Современные методы определения жесткости сосудов. Артериальная гипертензия. 2010;16(2):134–143.
5. Cantürk E, Çakal B, Karaca O, Omaygenç O, Salihi S, Özyüksel A et al. Changes in aortic pulse wave velocity and the predictors of improvement in arterial stiffness following aortic valve replacement. Ann Thorac Cardiovasc Surg. 2017;23(5):248–55. doi:10.5761/atcs.oa.17-00062
6. Милягина И. В., Милягин В. А., Шпынева З. М., Шпынев К. В., Лексина Ю. В., Пурыгина М. А. и др. Клиническое значение новых показателей жесткости сосудов. Вестник Смоленской государственной медицинской академии. 2010;1:34–41.
7. Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension. 2001;37(5):1236–1241. doi:10.1161/01.hyp.37.5.1236
8. Mattace-Raso FU, van der Cammen TJ, Hofman A, van Popele NM, Bos ML, Schalekamp MA et al. Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation. 2006;113(5):657–663. doi:10.1161/CIRCULATIONAHA.105.555235
9. Weber T, Auer J, Lamm G, O’Rourke MF, Eber B. Arterial stiffness, central blood pressures, and wave reflections in cardiomyopathy — implications for risk stratification. J Cardiac Fail. 2007;13(5):353–9. doi:10.1016/j.cardfail.2007.02.008
10. Chirinos JA, Zambrano JP, Chakko S, Veerani A, Schob A, Willens HJ et al. Aortic pressure augmentation predicts adverse cardiovascular events in patients with established coronary artery disease. Hypertension. 2005;45(5):980–985. doi:10.1161/01.HYP.0000165025.16381.44
11. Хубулава Г. Г., Гуляев Н. И., Кравчук В. Н., Любимов А. И., Волков А. М., Сизенко В. В. и др. Место дегенеративного стеноза клапана аорты в структуре приобретенных пороков сердца. Грудная и сердечно-сосудистая хирургия. 2018;60(1):28–35.
12. Iung B, Baron G, Butchart EG, Delahaye F, Gohlke-Bärwolf C, Levang OW et al. A prospective survey of patients with valvular heart disease in Europe: The Euro Heart Survey on Valvular Heart Disease. Eur Heart J. 2003;24(13):1231–1243. doi:10.1016/s0195-668x(03)00201-x
13. Бокерия Л. А., Милиевская Е. Б., Кудзоева З. Ф., Гудкова Р. Г. Болезни и врожденные аномалии системы кровообращения. Сердечно-сосудистая хирургия, 2018. Под ред. Л.А. Бокерия, Р. Г. Гудкова. М.: Издательство НМИЦССХ им. А. Н. Бакулева, 2019. 270 с.
14. Di Minno MND, Di Minno A, Ambrosino P, Songia P, Pepi M, Tremoli E et al. Cardiovascular morbidity and mortality in patients with aortic valve sclerosis: a systematic review and meta-analysis. Int J Cardiol. 2018;260:138–144. doi:10.1016/j.ijcard.2018.01.054
15. Rosenhek R, Zilberszac R, Schemper M, Czerny M, Mundigler G, Graf S et al. Natural history of very severe aortic stenosis. Circulation. 2010;121(1):151–156. doi:10.1161/CIRCULATIONAHA.109.894170
16. Gleason TG, Reardon MJ, Popma JJ, Deeb GM, Yakubov SJ, Lee JS et al. 5-year outcomes of self-expanding transcatheter versus surgical aortic valve replacement in high-risk patients. J Am Coll Cardiol. 2018;72(22):2687–2696. doi:10.1016/j.jacc.2018.08.2146
17. Liu PY, Tsai WC, Lin CC, Hsu CH, Haung YY, Chen JH. Invasive measurements of pulse wave velocity correlate with the degree of aortic valve calcification and severity associated with matrix metalloproteinases in elderly patients with aortic valve stenosis. Clin Sci (Lond). 2004;107(4):415–422. doi:10.1042/CS20040098
18. Van Bortel LM, Laurent S, Boutouyrie P, Chowienczyk P, Cruickshank JK, De Backer T et al. Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity. J Hypertens 2012;30(3):445–448. doi:10.1097/HJH.0b013e32834fa8b0
19. Saeed S, Saeed N, Grigoryan K, Chowienczyk P, Chambers JB, Rajani R. Determinants and clinical significance of aortic stiffness in patients with moderate or severe aortic stenosis. Int J Cardiol. 2020;315:99–104. doi:10.1016/j.echo.2013.12.014
20. Kidher E, Harling L, Ashrafian H, Naase H. Aortic stiffness as a marker of cardiac function and myocardial strain in patients undergoing aortic valve replacement. J Cardiothorac Surg. 2014;9(1):102. doi:10.1186/1749-8090-9-102
21. Bruschi G, Maloberti A, Sormani P, Colombo G, Nava S, Vallerio P et al. Arterial stiffness in aortic stenosis: relationship with severity and echocardiographic procedures response. High Blood Press Cardiovasc Prev. 2017;24(1):19–27. doi:10.1007/s40292-016-0176-x
22. Ranjan S, Grewal HK, Kasliwal RR, Trehan N, Bansal M. Aortic pulse wave velocity and its relationship with transaortic flow and gradients in patients with severe aortic stenosis undergoing aortic valve replacement. Indian Heart J. 2020;72(5):421–26. doi:10.1016/j.ihj.2020.06.010
23. Sera F, Russo C, Iwata S, Jin Z, Rundek T, Elkind MS et al. Arterial wave reflection and aortic valve calcification in an elderly community-based cohort. J Am Soc Echocardiogr. 2015;28(4):430– 436. doi:10.1016/j.echo.2014.12.011
24. Weisz SH, Magne J, Dulgheru R, Caso P, Piérard LA, Lancellotti P. Carotid artery and aortic stiffness evaluation in aortic stenosis. J Am Soc Echocardiogr. 2014;27(4):385–392. doi:10.1016/j.echo.2013.12.014
25. El-Chilali K, Farouk H, Abdelhafez M, Neumann T, Alotaibi S, Wendt D et al. Predictors of aortic pulse wave velocity in the elderly with severe aortic stenosis. Aging Clin Exp Res. 2016:28(3):519–525. doi:10.1007/s40520-015-0443-z
26. Kidher E, Harling L, Nihoyannopoulos P, Shenker N, Ashrafian H, Francis DP et al. High aortic pulse wave velocity is associated with poor quality of life in surgical aortic valve stenosis patients. Interact Cardiovasc Thorac Surg. 2014;19(2):189–197. doi:10.1093/icvts/ivu156
27. Singh A, Horsfield MA, Bekele S, Greenwood JP, Daw son DK, Berry C et al. Aortic stiffness in aortic stenosis assessed by cardiovascular MRI: a comparison between bicuspid and tricuspid valves. Eur Radiol. 2019;29(5):2340–2349. doi:10.1007/s00330-018-5775-6
28. Korkmaz L, Ağaç MT, Ata Korkmaz A, Erkan H, Acar Z, Çelik Ş. Relationship between aortic valve sclerosis and different vascular damage markers: an observational study. Anadolu Kardiyol Derg. 2013;13(5):452–456. doi:10.5152/akd.2013.143
29. Di Minno MND, Di Minno A, Songia P, Ambrosino P, Gripari P, Ravani A et al. Markers of subclinical atherosclerosis in patients with aortic valve sclerosis: a meta-analysis of literature studies. Int J Cardiol. 2016;223:364–370. doi:10.1016/j.ijcard.2016.08.122
30. Lee YS, Chou YY. Pathogenetic mechanism of senile calcific aortic stenosis: the role of apoptosis. Chin Med. 1998;111(10):934–939.
31. Mohler ER. Are atherosclerotic processes involved in aortic-valve calcification? Lancet. 2000;356(9229):524–525. doi:10.1016/S0140-6736(00)02572-1
32. Boudoulas KD, Wolfe B, Ravi Y, Lilly S, Nagaraja HN, Sai-Sudhakar CB. The aortic stenosis complex: aortic valve, atherosclerosis, aortopathy. J Cardiol. 2015;65(5):377–382. doi:10.1016/j.jjcc.2014.12.021
33. Chirinos JA, Segers P, Hughes T, Townsend R. Large-artery stiffness in health and disease: JACC State-of-the-Art Review. J Am Coll Cardiol. 2019;74(9):1237–1263. doi:10.1016/j.jacc.2019.07.012
34. Garcia J, Barker AJ, Markl M. The role of imaging of flow patterns by 4D flow MRI in aortic stenosis. JACC: Cardiovasc Imag. 2019;12(2):252–266. doi:10.1016/j.jcmg.2018.10.034
35. Nemes A, Galema TW, Geleijnse ML, Soliman OI, Yap SC, Anwar AM et al. Aortic valve replacement for aortic stenosis is associated with improved aortic distensibility at long-term follow-up. Am Heart J. 2007;153(1):147–151. doi:10.1016/j.ahj.2006.08.025
36. Melo R, Saraiva FA, Ferreira AF, Moreira S, Moreira R, J Cerqueira R et al. Endothelial function and vascular properties in severe aortic stenosis before and after aortic valve replacement surgery. Rev Port Cir Cardiotorac Vasc. 2017;24(3–4):153.
37. Musa TA, Uddin A, Fairbairn TA, Dobson LE, Sourbron SP, Steadman CD et al. Assessment of aortic stiffness by cardiovascular magnetic resonance following the treatment of severe aortic stenosis by TAVI and surgical AVR. J Cardiovasc Magn Reson. 2016;18(1):37. doi:10.1186/s12968-016-0256-z
38. Goudzwaard JA, Disegna E, de Ronde-Tillmans MJ, Lenzen MJ, de Jaegere PP, Mattace-Raso FU. Short-term changes of blood pressure and aortic stiffness in older patients after transcatheter aortic valve implantation. Clin Interv Aging. 2019;14:1379–1386. doi:10.2147/CIA.S211328
39. Müller C, Goliasch G, Schachinger S, Kastl S, Neunteufl T, Delle-Karth G et al. Transcatheter aortic valve replacement (TAVR) leads to an increase in the subendocardial viability ratio assessed by pulse wave analysis. PLoS One. 2018;13(11):1–11. doi:10.1371/journal.pone.0207537
40. Vavuranakis M, Vrachatis DA, Boudoulas H, Papaioannou TG, Moldovan C, Kariori MG et al. Effect of transcatheter aortic valve implantation on the ascending aorta’s elasticity. Clin Res Cardiol. 2012;101(11):895–899. doi:1007/s00392-012-0473-x
41. Katsanos S, Yiu KH, Clavel MA, Rodés-Cabau J, Leong D, van der Kley F et al. Impact of valvuloarterial impedance on 2-year outcome of patients undergoing transcatheter aortic valve implantation. J Am Soc Echocardiogr. 2013;26(7):691–698. doi:10.1016/j.echo.2013.04.003
42. Terentes-Printzios D, Gardikioti V, Aznaouridis K, Latsios G, Drakopoulou M, Siasos G et al. The impact of transcatheter aortic valve implantation on arterial stiffness and wave reflections. Int J Cardiol. 2021;323:213–219. doi:10.1016/j.ijcard.2020.08.040
43. Jones DR, Chew DP, Horsfall MJ, Sinhal AR, Joseph MX, Baker RA et al. Impact of increased augmentation index and valvuloarterial impedance on symptom recovery after aortic valve replacement for severe aortic stenosis. Int J Cardiol Heart Vasc. 2021;32:100705. doi:10.1016/j.ijcha.2020.100705
44. Stefanadis C, Vlachopoulos C, Karayannacos P, Boudoulas H, Stratos C, Filippides T et al. Effect of vasa vasorum flow on structure and function of the aorta in experimental animals. Circulation. 1995;91(10):2669–2678. doi:10.1161/01.cir.91.10.2669
45. Pagoulatou S, Stergiopulos N, Bikia V, Rovas G, Licker MJ, Müller H et al. Acute effects of transcatheter aortic valve replacement on the ventricular-aortic interaction. Am J Physiol Heart Circ Physiol. 2020;319(6): H1451–H1458. doi:10.1152/ajpheart.00451.2020
46. Broyd CJ, Patel K, Pugliese F, Chehab O, Mathur A, Baumbach A et al. Pulse wave velocity can be accurately measured during transcatheter aortic valve implantation and used for post-procedure risk stratification. J Hypertens. 2019;37(9):1845–1852. doi:10.1097/HJH.0000000000002141
47. Kurt IH, Şen Ö, Kuçükosmanoğlu M, Salkın FÖ, Urgun ÖD, Şahin Ş et al. The influence of aortic pulse wave velocity on short-term functional capacity in patients with mild paravalvular regurgitation following transcatheter aortic valve implantation. Braz J Cardiovasc Surg. 2020;35(4):504–511. doi:10.21470/1678-9741-2019-0454
48. Tanaka T, Asami M, Yahagi K, Ninomiya K, Okuno T, Horiuchi Y et al. Prognostic impact of arterial stiffness following transcatheter aortic valve replacement. J Cardiol. 2021:S 0914– 5087(21)00020–4. doi:10.1016/j.jjcc.2021.01.007
49. van der Waaij KM, Heusinkveld MHG, Delhaas T, Kroon AA, Reesink KD. Do treatment-induced changes in arterial stiffness affect left ventricular structure? A meta-analysis. J Hypertens. 2019;37(2):253–263. doi:10.1097/HJH.0000000000001918