Роль оксида азота в улучшении функции эндотелия и сердечно-сосудистого здоровья: фокус на небиволол

G. L. Bakris; J. N. Basile; T. D. Giles; A. A. Taylor

Статья

Роль оксида азота в улучшении функции эндотелия и сердечно-сосудистого здоровья: фокус на небиволол

G. L. Bakris, J. N. Basile, T. D. Giles, A. A. Taylor

2011

Согласно современным клиническим рекомендациям, β-адреноблокаторы (β-АБ) показаны для лечения пациентов с артериальной гипертензией (АГ), в особенности, с выраженной сердечно-сосудистой патологией и высоким сердечно-сосудистым риском. Определенную настороженность вызывают данные о связи терапии традиционными β-АБ с неблагоприятными клиническими исходами, по сравнению с другими классами антигипертензивных препаратов (АГП). Прием традиционных β-АБ может ассоциироваться с ухудшением качества жизни, а также липидного и углеводного обменов. β-АБ представляют собой разнородную группу АГП, включающую неселективные препараты, кардиоселективные препараты без вазодилатирующих свойств, а также вазодилатирующие препараты, сочетающие неселективность в отношении β-рецепторов с α-блокирующим действием, либо кардиоселективность с отсутствием α-блокады. В обзоре обсуждаются фармакологические и гемодинамические различия между традиционными β-АБ без вазодилатирующей активности и вазодилатирующими β-АБ, с фокусом на небиволол — кардиоселективный β-АБ с вазодилатирующими свойствами. Данные различия могут иметь важное клиническое значение, в частности, при лечении осложненной АГ (например, у пациентов с сахарным диабетом, кардиометаболическим синдромом, пожилых больных и пациентов афроамериканского происхождения). Таким образом, при выборе того или иного β-АБ следует учитывать механизм его действия.

Bakris G. L., Basile J. N., Giles T. D., Taylor A. A. Роль оксида азота в улучшении функции эндотелия и сердечно-сосудистого здоровья: фокус на небиволол. Кардиоваскулярная терапия и профилактика. 2011;10(2):116-121.

Цитирование

Список литературы

1. Chobanian AV, Bakris GL, Black HR, et al, for the National Heart, Lung, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure and the National High Blood Pressure Education Program Coordinating Committee. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 2003; 289: 2560-72.

2. Weber MA. The role of the new _-blockers in treating cardiovascular disease. Am J Hypertens 2005; 18(pt 2): 169S-76.

3. Weber MA, Bakris GL, Tarka EA, et al. Efficacy of a once-daily formulation of carvedilol for the treatment of hypertension. J Clin Hypertens (Greenwich) 2006; 8: 840-9.

4. Morgan T, Lauri J, Bertram D, Anderson A. Effect of different antihypertensive drug classes on central aortic pressure. Am J Hypertens 2004; 17: 118-23.

5. Pedersen ME, Cockcroft JR. The vasodilatory beta-blockers. Curr Hypertens Rep 2007; 9: 269-77.

6. Mason PR, Kubant R, Jacob RF, et al. Effect of nebivolol on endothelial nitric oxide and peroxynitrite release in hypertensive animals: role of antioxidant activity. J Cardiovasc Pharmacol 2006; 48: 862-9.

7. Stewart FM, Freeman DJ, Ramsay JE, et al. Longitudinal assessment of maternal endothelial function and markers of inflammation and placental function through pregnancy in lean and obese mothers. J Clin Endocrinol Metab 2007; 92: 969-75.

8. Arkin JM, Alsdorf R, Bigornia S, et al. Relation of cumulative weight burden to vascular endothelial dysfunction in obesity. Am J Cardiol 2008; 101: 98-101.

9. Fonseca V, Jawa A. Endothelial and erectile dysfunction, diabetes mellitus, and the metabolic syndrome: common pathways and treatments? Am J Cardiol 2005; 96: 13M-8.

10. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med 1999; 340: 115-26.

11. Dzau VJ, Antman EM, Black HR, et al. The cardiovascular disease continuum validated: clinical evidence of improved patient outcomes. Part I: pathophysiology and clinical trial evidence (risk factors through stable coronary artery disease). Circulation 2006; 114: 2850-70.

12. Kannel WB. Risk stratification in hypertension: new insights from the Framingham Study. Am J Hypertens 2000; 13(pt 2): 3S-10.

13. Golden SH, Folsom AR, Coresh J, et al. Risk factor groupings related to insulin resistance and their synergistic effects on subclinical atherosclerosis: the Atherosclerosis Risk in Communities Study. Diabetes 2002; 51: 3069-76.

14. Panza JA, Quyyumi AA, Callahan TS, Epstein SE. Effect of antihypertensive treatment on endothelial-dependent vascular relaxation in patients with essential hypertension. JACC 1993; 21: 1145-51.

15. Taddei S, Virdis A, Mattei P, et al. Endotheliumdependent forearm vasodilation is reduced in normotensive subjects with familial history of hypertension. J Cardiovasc Pharmacol 1992; 20(suppl 12): S193-5.

16. Panza JA, Casino PR, Badar DM, Quyyumi AA. Effect of increased availability of endothelium-derived nitric oxide precursor on endothelium-dependent vascular relaxation in normal subjects and in patients with essential hypertension. Circulation 1993; 87: 1475-81.

17. Brett SE, Cockcroft JR, Mant TG, et al. Haemodynamic effects of inhibition of nitric oxide synthase and of Larginine at rest and during exercise. J Hypertens 1998; 16: 429-35.

18. Dhakam Z, Yasmin, McEniery CM, et al. A comparison of atenolol and nebivolol in isolated systolic hypertension. J Hypertens 2008; 26: 351-6.

19. Bristow MR. β-Adrenergic receptor blockade in chronic heart failure. Circulation 2000; 101: 558-69.

20. Berecek KH, Carey RM. Adrenergic and dopaminergic receptors and actions. In: Izzo JL, Black HR, eds. Hypertension Primer, 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 2003:1-4.

21. Bristow MR, Nelson P, Minobe W, Johnson C. Characterization of β1-adrenergic receptor selectivity of nebivolol and various other betablockers in human myocardium. Am J Hypertens. 2005;18(suppl 4s): 51A-52A. Poster P-121.

22. Van de Water A, Janssens W, Van Neuten J, et al. Pharmacological and hemodynamic profile of nebivolol, a chemically novel, potent, and selective β1-adrenergic antagonist. J Cardiovasc Pharmacol 1988; 11: 552-63.

23. Brixius K, Bundkirchen A, Bölck B, et al. Nebivolol, bucindolol, metoprolol and carvedilol are devoid of intrinsic sympathomimetic activity in human myocardium. Br J Pharmacol 2001; 133: 1330-8.

24. Frishman WH. _1-adrenoceptor selectivity is maintained with increasing doses of the vasodilatory β-blocker nebivolol. J Clin Hypertens (Greenwich) 2008; 10(suppl A): A21.

25. Ritter JM. Nebivolol: endothelium-mediated vasodilating effect. J Cardiovasc Pharmacol 2001; 38(suppl 3): S13-6.

26. Bowman AJ, Chen CP, Ford GA. Nitric oxide mediated venodilator effects of nebivolol. Br J Clin Pharmacol 1994; 38: 199-204.

27. Tzemos N, Lim PO, MacDonald TM. Nebivolol reverses endothelial dysfunction in essential hypertension: a randomized, double-blind, crossover study. Circulation 2001; 104: 511-4.

28. Campia U, Choucair WK, Bryant MB, et al. Reduced endothelium-dependent and -independent dilation of conductance arteries in African Americans. JACC 2002; 40: 754-60.

29. Mason RP, Kalinowski L, Jacob RF, et al. Nebivolol reduces nitroxidative stress and restores nitric oxide bioavailability in endothelium of black Americans. Circulation 2005; 112: 3795-801.

30. Kamp O, Sieswerda GT, Visser CA. Comparison of effects on systolic and diastolic left ventricular function of nebivolol versus atenolol in patients with uncomplicated essential hypertension. Am J Cardiol 2003; 92: 344-8.

31. Dahlöf B, Devereux RB, Kjeldsen SE, et al, for the LIFE Study Group. Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomized trial against atenolol. Lancet 2002; 359: 995-1003.

32. Dahlöf B, Sever PS, Poulter NR, et al, for the ASCOT Investigators. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 2005; 366: 895-906.

33. Williams B, Lacy PS, Thom SM, et al, for the CAFE Investigators, the Anglo-Scandinavian Cardiac Outcomes Trial Investigators, and the CAFE Steering Committee and Writing Committee. Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study. Circulation 2006; 113: 1213-25.

34. Lindholm LH, Carlberg B, Samuelsson O. Should β-blockers remain first choice in the treatment of primary hypertension? A meta-analysis. Lancet 2005; 366: 1545-53.

35. Saunders E, Smith WB, DeSalvo KB, Sullivan WA. The efficacy and tolerability of nebivolol in hypertensive African American patients. J Clin Hypertens (Greenwich) 2007; 9: 866-75.

36. Celik T, Iyisoy A, Kursaklioglu H, et al. Comparative effects of nebivolol and metoprolol on oxidative stress, insulin resistance, plasma adiponectin and soluble P-selectin levels in hypertensive patients. J Hypertens 2006; 24: 591-6.

37. Boydak B, Nalbantgil S, Fici F, et al. A randomised comparison of the effects of nebivolol and atenolol with and without chlorthalidone on the sexual function of hypertensive men. Clin Drug Invest 2005; 25: 409-16.

38. Brixius K, Middeke M, Lichtenthal A, et al. Nitric oxide, erectile dysfunction and beta-blocker treatment (MR NOED study): benefit of nebivolol versus metoprolol in hypertensive men. Clin Exp Pharmacol Physiol 2007; 34: 327-31.

39. Flather MD, Shibata MC, Coats AJS, et al, for the SENIORS Investigators. Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS). Eur Heart J 2005; 26: 215-25.

40. Basile J. One size does not fit all: the role of vasodilating β-blockers in controlling hypertension as a means of reducing cardiovascular and stroke risk. Am J Med 2010; 123: S9-15.

41. Giles TD. The role of vasodilating β-blockers in patients with complicated hypertension: focus on nebivolol. Am J Med. 2010;.

42. Taylor AA, Bakris GL. The role of vasodilating β-blockers in patients with hypertension and the cardiometabolic syndrome. Am J Med 2010; 123: S21-6.

Документы

Информация

Автор

G. L. Bakris Hypertensive Diseases Unit, Department of Medicine, University of Chicago Medical Center
J. N. Basile Seinsheimer Cardiovascular Health Program, College of Medicine, Medical University of South Carolina, Ralph H. Johnson VA Medical Center
T. D. Giles Department of Medicine, Tulane University School of Medicine
A. A. Taylor Departments of Medicine, Pharmacology, and Molecular Physiology, Baylor College of Medicine

Название журнала

Кардиоваскулярная терапия и профилактика

Ключевые слова

Статья