Статья
Провоспалительные факторы и депрессия при инфаркте миокарда
Цель. Оценить взаимосвязь факторов воспаления с уровнем тревоги (Тр) и депрессии (Д) у пациентов с инфарктом миокарда (ИМ). Материал и методы. 100 пациентов с ИМ, находившихся на стационарном лечении по поводу Q-ИМ; cредний возраст пациентов — 62,0±1,3 года. Методы обследования психологического статуса: шкала депрессии Цунга, шкалы личностной и реактивной тревожности Спилбергера-Ханина. Для оценки взаимосвязи факторов воспаления с уровнями Тр и Д в качестве маркеров воспаления оценивались уровни интерлейкинов (ИЛ) ИЛ– 1β, ИЛ-6, ИЛ-8, ИЛ-10 и С-реактивного белка (СРБ). Результаты. Наличие у пациентов в ранние сроки после перенесенного ИМ симптомов Д и повышенной Тр ассоциируется с высоким риском развития в течение года сердечно-сосудистых событий. Среди пациентов с ИМ одного класса тяжести наличие симптомов Д и Тр ассоциировалось с более высоким уровнем провоспалительных цитокинов ИЛ-1β, ИЛ-6, ИЛ-8 и ИНФ-γ. Заключение. Одним их механизмов, определяющих неблагоприятный прогноз у данной категории пациентов, является активация субклинического воспаления.
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