Статья
Растворимый ST2 – как биомаркер, инструмент стратификации риска и терапевтическая мишень у пациентов с хронической сердечной недостаточностью
Настоящий обзор посвящен обсуждению вопросов возможности использования растворимого ST2, как биомаркера СН, с целью диагностики, стратификации риска негативных событий, оценки прогноза и эффективности лечения у пациентов с ХСН. Циркулирующие биомаркеры – неотъемлемый элемент алгоритмов постановки диагноза, стратификации риска и оценки прогноза у пациентов с СН. Признанный «золотой» стандарт – натрийуретические пептиды – имеет ряд известных ограничений, и в последние годы появилось множество новых субстанций – кандидатов в биомаркеры СН. В качестве одного из наиболее перспективных рассматривается биомаркер «механического» миокардиального стресса – растворимый ST2, и в настоящем обзоре обсуждаются вопросы возможности его использования в клинической практике у пациентов с ХСН.
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