ТЕХНИЧЕСКИЕ АСПЕКТЫ РАЗРАБОТКИ ПОЛНОСТЬЮ ИСКУССТВЕННОГО СЕРДЦА

Приходько Юрий Михайлович; Медведев Алексей Елизарович; Фомин Василий Михайлович; Жульков Максим Олегович; Сирота Дмитрий Андреевич; Протопопов Андрей Владимирович; Чернявский Александр Михайлович

Статья

ТЕХНИЧЕСКИЕ АСПЕКТЫ РАЗРАБОТКИ ПОЛНОСТЬЮ ИСКУССТВЕННОГО СЕРДЦА

Приходько Юрий Михайлович,

Медведев Алексей Елизарович,

Фомин Василий Михайлович,

Жульков Максим Олегович,

Сирота Дмитрий Андреевич,

Протопопов Андрей Владимирович,

Чернявский Александр Михайлович

2025

https://doi.org/10.17802/2306-1278-2025-14-5-256-272

Основные положения:Разработка полностью искусственного сердца представляет собой комплексную инженерную задачу, направленную на создание долговременной замены терминально больному сердцу. Основные усилия сосредоточены на обеспечении надежной насосной функции и биосовместимости.В статье рассмотрены ключевые технические аспекты TAH, включая конструкцию насосов, выбор материалов и системы управления, на основе анализа современных разработок и научной литературы. Особое внимание уделено решению проблем гемосовместимости.Одной из главных технических проблем при создании TAH остается обеспечение эффективного и безопасного долгосрочного энергоснабжения имплантированного устройства. Поиск решений в этой области является критически важным для успеха технологии. РезюмеВ статье рассматриваются критически важные инженерные аспекты: проектирование миниатюрных, высоконадежных насосных систем (роторных/пульсирующих); разработка исключительно биосовместимых материалов, предотвращающих тромбоз и кальцификацию; создание эффективных систем управления кровотоком с автономной адаптацией под потребности пациента; интеграция перспективных источников энергии и систем беспроводной передачи. Особое внимание уделяется минимизации гемолиза и достижению гемодинамической совместимости.

Приходько Юрий Михайлович, Медведев Алексей Елизарович, Фомин Василий Михайлович, Жульков Максим Олегович, Сирота Дмитрий Андреевич, Протопопов Андрей Владимирович, Чернявский Александр Михайлович ТЕХНИЧЕСКИЕ АСПЕКТЫ РАЗРАБОТКИ ПОЛНОСТЬЮ ИСКУССТВЕННОГО СЕРДЦА. Комплексные проблемы сердечно-сосудистых заболеваний. 2025;14(5):256-272. https://doi.org/10.17802/2306-1278-2025-14-5-256-272

Цитирование

Список литературы

1. Alexander Eskandary F, Kohl M, Dunkler D, Aliabadi A, Grömmer M, Schiferer A, et al. Lack of donor and recipient age interaction in cardiac transplantation. Journal of Heart and Lung Transplantation 2014;33:629–35. https://doi.org/10.1016/j.healun.2014.02.005.

2. Polyakov DS, Fomin I V., Belenkov YN, Mareev VY, Ageev FT, Artemyeva EG. Chronic heart failure in the Russian Federation: what has changed over 20 years of follow-up? Results of the EPOCH-CHF study. Kardiologiya 2021;61:4–14. https://doi.org/10.18087/cardio.2021.4.n1628.

3. Watanabe T, Seguchi O, Yanase M, Fujita T, Murata Y, Sato T, et al. Donor-transmitted atherosclerosis associated with worsening cardiac allograft vasculopathy after heart transplantation: Serial volumetric intravascular ultrasound analysis. Transplantation 2017;101:1310–9. https://doi.org/10.1097/TP.0000000000001322.

4. Sathianathan S, Bhat G. Heart Transplant Donor Selection Guidelines: Review and Recommendations. Curr Cardiol Rep 2022;24:119–30. https://doi.org/10.1007/s11886-021-01631-y.

5. Malik A, Brito D, Vaqar S, Chhabra L. Congestive Heart Failure. StatPearls 2022.

6. Yazji JH, Garg P, Wadiwala I, Alomari M, Alamouti-Fard E, Hussain MWA, et al. Expanding Selection Criteria to Repairable Diseased Hearts to Meet the Demand of Shortage of Donors in Heart Transplantation. Cureus 2022. https://doi.org/10.7759/cureus.25485.

7. Jawitz OK, Fudim M, Raman V, Bryner BS, DeVore AD, Mentz RJ, et al. Reassessing Recipient Mortality Under the New Heart Allocation System: An Updated UNOS Registry Analysis. JACC Heart Fail 2020;8:548–56. https://doi.org/10.1016/j.jchf.2020.03.010.

8. Baldwin ACW, Gemmato CJ, Cohn WE, Frazier OH. Feasibility of long-term continuous flow total heart replacement in calves. International Journal of Artificial Organs 2022;45:44–51. https://doi.org/10.1177/0391398820987851.

9. Morris DT, Couves CM. Experiences with a sac-type artificial heart. Can Med Assoc J 1971;105:483.

10. Vis A, Arfaee M, Khambati H, Slaughter MS, Gummert JF, Overvelde JTB, et al. The ongoing quest for the first total artificial heart as destination therapy. Nat Rev Cardiol 2022;19:813–28. https://doi.org/10.1038/S41569-022-00723-8.

11. Cohrs NH, Petrou A, Loepfe M, Yliruka M, Schumacher CM, Kohll AX, et al. A Soft Total Artificial Heart—First Concept Evaluation on a Hybrid Mock Circulation. Artif Organs 2017;41:948–58. https://doi.org/10.1111/AOR.12956.

12. Guex LG, Jones LS, Xavier Kohll A, Walker R, Meboldt M, Falk V, et al. Increased Longevity and Pumping Performance of an Injection Molded Soft Total Artificial Heart. Soft Robot 2021;8:588–93. https://doi.org/10.1089/SORO.2019.0154.

13. Mihaylov D, Verkerke GJ, Rakhorst G. Mechanical circulatory support systems - A review. Technology and Health Care 2000;8:251–66. https://doi.org/10.3233/THC-2000-8501;PAGE:STRING:ARTICLE/CHAPTER.

14. Szabo Z, Holm J, Najar A, Hellers G, Pieper IL, Casimir Ahn H. Scandinavian Real Heart (SRH) 11 Implantation as Total Artificial Heart (TAH)-Experimental Update. J Clin Exp Cardiolog 2018;09. https://doi.org/10.4172/2155-9880.1000578.

15. Pelletier B, Spiliopoulos S, Finocchiaro T, Graef F, Kuipers K, Laumen M, et al. System overview of the fully implantable destination therapy-ReinHeart-total artificial heart. European Journal of Cardio-Thoracic Surgery 2015;47:80–6. https://doi.org/10.1093/EJCTS/EZU321.

16. Tozzi P, Maertens A, Emery J, Joseph S, Kirsch M, Avellan F. An original valveless artificial heart providing pulsatile flow tested in mock circulatory loops. International Journal of Artificial Organs 2017;40:683–9. https://doi.org/10.5301/IJAO.5000634.

17. Roche ET, Horvath MA, Wamala I, Alazmani A, Song SE, Whyte W, et al. Soft robotic sleeve supports heart function. Sci Transl Med 2017;9. https://doi.org/10.1126/SCITRANSLMED.AAF3925.

18. Weymann A, Foroughi J, Vardanyan R, Punjabi PP, Schmack B, Aloko S, et al. Artificial Muscles and Soft Robotic Devices for Treatment of End-Stage Heart Failure. Advanced Materials 2023;35. https://doi.org/10.1002/ADMA.202207390.

19. Slaughter MS, Pagani FD, Rogers JG, Miller LW, Sun B, Russell SD, et al. Clinical management of continuous-flow left ventricular assist devices in advanced heart failure. Journal of Heart and Lung Transplantation 2010;29. https://doi.org/10.1016/j.healun.2010.01.011.

20. Kleinheyer M, Greatrex N, Nestler F, Timms DL. BiVACOR Total Artificial Heart and Future Concepts. Mechanical Circulatory Support 2023:1–17. https://doi.org/10.1007/978-3-030-86172-8_14-1.

21. Fukamachi K, Horvath DJ, Massiello AL, Fumoto H, Horai T, Rao S, et al. An innovative, sensorless, pulsatile, continuous-flow total artificial heart: Device design and initial in vitro study. Journal of Heart and Lung Transplantation 2010;29:13–20. https://doi.org/10.1016/J.HEALUN.2009.05.034.

22. Петухов Д.С, Селищев С.В., Телышев Д.В. Перспективы развития технологий полной замены функции сердца с помощью механических систем поддержки кровообращения. Медицинская Техника 2015;5:5–7.

23. Bartel S, Trawiński T. The influence of the micropump`s winding shape and magnetic circuit configuration on the generated electromagnetic torque characteristic. Part I: FEM analysis. Electrotechnical Review n.d.;R. 92, nr 5:240–4.

24. Feng J, Cohn WE, Parnis SM, Sodha NR, Clements RT, Sellke N, et al. New continuous-flow total artificial heart and vascular permeability. Journal of Surgical Research 2015;199:296–305. https://doi.org/10.1016/j.jss.2015.06.035.

25. Feng J, Cohn WE, Parnis SM, Sodha NR, Clements RT, Sellke N, et al. New Continuous-Flow Total Artificial Heart and Vascular Permeability. J Surg Res 2015;199:296. https://doi.org/10.1016/J.JSS.2015.06.035.

26. Lebreton G, Mastroianni C, Amour J, Leprince P. Implantation of Two HVADs Used as a Total Artificial Heart: A New Approach. Annals of Thoracic Surgery 2019;107:e165–7. https://doi.org/10.1016/j.athoracsur.2018.07.067.

27. Mulvihill MS, Joseph JT, Daneshmand MA, Patel CB, Milano CA, Schroder JN. Usefulness of 2 centrifugal ventricular assist devices in a total artificial heart configuration: A preliminary report. Journal of Heart and Lung Transplantation 2017;36:1266–8. https://doi.org/10.1016/j.healun.2017.05.019.

28. Cohn WE, Handy KM, Parnis SM, Conger JL, Winkler JA, Frazier OH. Eight-year experience with a continuous-flow total artificial heart in calves. ASAIO Journal 2014;60:25–30. https://doi.org/10.1097/MAT.0000000000000027.

29. Pirk J, Maly J, Szarszoi O, Urban M, Kotulak T, Riha H, et al. Total artificial heart support with two continuous-flow ventricular assist devices in a patient with an infiltrating cardiac sarcoma. ASAIO Journal 2013;59:178–80. https://doi.org/10.1097/MAT.0B013E3182816CD9.

30. Frazier OH, Cohn WE. Continuous-Flow Total Heart Replacement Device Implanted in a 55-Year-Old Man with End-Stage Heart Failure and Severe Amyloidosis. Tex Heart Inst J 2012;39:542.

31. Strueber M, Schmitto JD, Kutschka I, Haverich A. Placement of 2 implantable centrifugal pumps to serve as a total artificial heart after cardiectomy. Journal of Thoracic and Cardiovascular Surgery 2012;143:507–9. https://doi.org/10.1016/j.jtcvs.2011.07.034.

32. Frazier OH, Cohn WE, Tuzun E, Winkler JA, Gregoric ID. Continuous-Flow Total Artificial Heart Supports Long-Term Survival of a Calf. Tex Heart Inst J 2009;36:568.

33. Daneshmand MA, Bishawi M, Milano CA, Schroder JN. The HeartMate 6. ASAIO Journal 2020;66:E46–9. https://doi.org/10.1097/MAT.0000000000001011.

34. Lima B, Mack M, Gonzalez-Stawinski G V. Ventricular assist devices: The future is now. Trends Cardiovasc Med 2015;25:360–9. https://doi.org/10.1016/j.tcm.2014.11.008.

35. Slepian MJ, Alemu Y, Soares JS, G. Smith R, Einav S, Bluestein D. The SyncardiaTM total artificial heart: In vivo, in vitro, and computational modeling studies. J Biomech 2013;46:266–75. https://doi.org/10.1016/j.jbiomech.2012.11.032.

36. Glynn J, Song H, Hull B, Withers S, Gelow J, Mudd J, et al. The OregonHeart Total Artificial Heart: Design and Performance on a Mock Circulatory Loop. Artif Organs 2017;41:904–10. https://doi.org/10.1111/aor.12959.

37. Kurita N, Ishikawa T, Saito N, Masuzawa T, Timms DL. A Double-Sided Stator Type Axial Bearingless Motor Development for Total Artificial Heart. IEEE Trans Ind Appl 2019;55:1516–23. https://doi.org/10.1109/TIA.2018.2884609.

38. Earnshaw S. On the Nature of the Molecular Forces which Regulate the Constitution of the Luminiferous Ether. Trans Camb Phil Soc 1842;7:97–114.

39. Greatrex NA, Timms DL, Kurita N, Palmer EW, Masuzawa T. Axial magnetic bearing development for the BiVACOR rotary BiVAD/TAH. IEEE Trans Biomed Eng 2010;57:714–21. https://doi.org/10.1109/TBME.2009.2033389.

40. Kobayashi M, Horvath DJ, Mielke N, Shiose A, Kuban B, Fukamachi K, et al. Progress on the Design and Development of the Continuous-Flow Total Artificial Heart 2013;36:705–13. https://doi.org/10.1111/j.1525-1594.2012.01489.x.Progress.

41. Hirschhorn M, Catucci N, Day SW, Stevens RM, Tchantchaleishvili V, Throckmorton AL. Channel impeller design for centrifugal blood pump in hybrid pediatric total artificial heart: Modeling, magnet integration, and hydraulic experiments 2023;47:680–94. https://doi.org/10.1111/aor.14480.Channel.

42. Schoeb R, Barletta N, Fleischli A, Bourque K, Gernes D, Loree H, et al. HEARTMATE III: BEARINGLESS MOTOR DESIGN FOR A MAGLEV CENTRIFUGAL LVAD. ASAIO Journal 2000;46.

43. Shinshi T, Hijikata W, Mamiya T, Takatani S. Development of Extracorporeal Maglev Blood Pumps 2014:433–6.

44. Qian KX, Zeng P, Ru WM, Yuan HY. New concepts and new design of permanent maglev rotary artificial heart blood pumps. Med Eng Phys 2006;28:383–8. https://doi.org/10.1016/J.MEDENGPHY.2005.07.007.

45. Earnshaw, S. On the Nature of the Molecular Forces which Regulate the Constitution of the Luminiferous Ether. TCaPS 1848;7:97.

46. Kirklin JK, Pagani FD, Kormos RL, Stevenson LW, Blume ED, Myers SL, et al. Eighth annual INTERMACS report: Special focus on framing the impact of adverse events. Journal of Heart and Lung Transplantation 2017;36:1080–6. https://doi.org/10.1016/j.healun.2017.07.005.

47. Potapov E V., Kaufmann F, Müller M, Mulzer J, Falk V. Longest Ongoing Support (13 Years) with Magnetically Levitated Left Ventricular Assist Device. ASAIO Journal 2020;66:E121–2. https://doi.org/10.1097/MAT.0000000000001131.

48. Healy AH, McKellar SH, Drakos SG, Koliopoulou A, Stehlik J, Selzman CH. PHYSIOLOGIC EFFECTS OF CONTINUOUS-FLOW LEFT VENTRICULAR ASSIST DEVICES. J Surg Res 2016;202:363. https://doi.org/10.1016/J.JSS.2016.01.015.

49. Bhimaraj A, Uribe C, Suarez EE. Physiological impact of continuous flow on end-organ function: clinical implications in the current era of left ventricular assist devices. Methodist Debakey Cardiovasc J 2015;11:12–7. https://doi.org/10.14797/MDCJ-11-1-12.

50. Purohit SN, Cornwell WK, Pal JD, Lindenfeld JA, Ambardekar A V. Living Without a Pulse: The Vascular Implications of Continuous-Flow Left Ventricular Assist Devices. Circ Heart Fail 2018;11. https://doi.org/10.1161/CIRCHEARTFAILURE.117.004670.

51. Meriglier E, Fignon A, Debouverie O, Roy-Péaud F, Roblot P. Un syndrome cérébelleux révélant un syndrome de Gougerot-Sjögren. Rev Med Interne 2013;34:A131. https://doi.org/10.1016/J.REVMED.2013.10.227.

52. Glynn J, Song H, Hull B, Withers S, Gelow J, Mudd J, et al. The OregonHeart Total Artificial Heart: Design and Performance on a Mock Circulatory Loop. Artif Organs 2017;41:904–10. https://doi.org/10.1111/AOR.12959.

53. Bierewirtz T, Narayanaswamy K, Giuffrida R, Rese T, Bortis D, Zimpfer D, et al. A Novel Pumping Principle for a Total Artificial Heart. IEEE Trans Biomed Eng 2024;71:446–55. https://doi.org/10.1109/TBME.2023.3306888.

54. Giuffrida R, Senti R, Kolar JW, Bierewirtz T, Narayanaswamy K, Granegger M, et al. Design and Realization of a Highly-Compact Tubular Linear Actuator for a Novel Total Artificial Heart 2023. https://doi.org/10.36227/TECHRXIV.22725674.V1.

55. Giuffrida R V., Horat A, Bortis D, Bierewirtz T, Narayanaswamy K, Granegger M, et al. Linear-Rotary Position Control System With Enhanced Disturbance Rejection for a Novel Total Artificial Heart. IEEE Open Journal of the Industrial Electronics Society 2024;5:359–75. https://doi.org/10.1109/OJIES.2024.3385865.

56. Kleinheyer M, Timms DL, Tansley GD, Nestler F, Greatrex NA, Frazier OH, et al. Rapid Speed Modulation of a Rotary Total Artificial Heart Impeller. Artif Organs 2016;40:824–33. https://doi.org/10.1111/aor.12827.

57. Shiose A, Nowak K, Horvath DJ, Massiello AL, Golding LAR, Fukamachi K. Speed Modulation of the Continuous-Flow Total Artificial Heart to Simulate a Physiologic Arterial Pressure Waveform. ASAIO Journal 2010;56:403–9. https://doi.org/10.1097/MAT.0b013e3181e650f8.

58. Fukamachi K, Karimov JH, Sunagawa G, Horvath DJ, Byram N, Kuban BD, et al. Generating Pulsatility by Pump Speed Modulation with Continuous-Flow Total Artificial Heart in Awake Calves. J Artif Organs 2017;20:381. https://doi.org/10.1007/S10047-017-0958-5.

59. Miyamoto T, Horvath DJ, Horvath DW, Kuban BD, Fukamachi K, Karimov JH. Analysis of Cleveland Clinic continuous-flow total artificial heart performance using the Virtual Mock Loop: Comparison with an in vivo study. Artif Organs 2020;44:375–83. https://doi.org/10.1111/AOR.13574.

60. Abe Y, Isoyama T, Saito I, Inoue Y, Ishii K, Sato M, et al. Animal Experiments of the Helical Flow Total Artificial Heart. Artif Organs 2015;39:670–80. https://doi.org/10.1111/AOR.12543.

61. Fox C, Chopski S, Murad N, Allaire P, Mentzer R, Rossano J, et al. Hybrid Continuous-Flow Total Artificial Heart. Artif Organs 2018;42:500–9. https://doi.org/10.1111/AOR.13080.

62. Jurney PL, Glynn JJ, Dykan I V., Hagen MW, Kaul S, Wampler RK, et al. Characterization of a pulsatile rotary total artificial heart. Artif Organs 2021;45:135–42. https://doi.org/10.1111/AOR.13810.

63. Cohn WE, Timms DL, Frazier OH. Total artificial hearts: Past, present, and future. Nat Rev Cardiol 2015;12:609–17. https://doi.org/10.1038/NRCARDIO.2015.79.

64. Nestler F, Timms DL, Stevens M, Bradley AP, Wilson SJ, Kleinheyer M, et al. Investigation of the inherent left-right flow balancing of rotary total artificial hearts by means of a resistance box. Artif Organs 2020;44:584–93. https://doi.org/10.1111/AOR.13631.

65. Jurney P, Glynn J, Dykan I, Hagen M, Kaul S, Wampler R, et al. Characterization of a Pulsatile Rotary Total Artificial Heart. Artif Organs 2020;45. https://doi.org/10.1111/aor.13810.

66. Horvath D, Byram N, Karimov JH, Kuban B, Sunagawa G, Golding LAR, et al. Mechanism of Self-Regulation and In Vivo Performance of the Cleveland Clinic Continuous-Flow Total Artificial Heart. Artif Organs 2017;41:411–7. https://doi.org/10.1111/AOR.12780.

67. Au SLC, McCormick D, Lever N, Budgett D. Thermal evaluation of a hermetic transcutaneous energy transfer system to power mechanical circulatory support devices in destination therapy. Artif Organs 2020;44:955–67. https://doi.org/10.1111/AOR.13679.

68. Goldstein DJ, Naftel D, Holman W, Bellumkonda L, Pamboukian S V., Pagani FD, et al. Continuous-flow devices and percutaneous site infections: Clinical outcomes. Journal of Heart and Lung Transplantation 2012;31:1151–7. https://doi.org/10.1016/j.healun.2012.05.004.

69. Dissanayake TD, Budgett DM, Hu P, Bennet L, Pyner S, Booth L, et al. A novel low temperature transcutaneous energy transfer system suitable for high power implantable medical devices: Performance and validation in sheep. Artif Organs 2010;34:160–7. https://doi.org/10.1111/j.1525-1594.2009.00992.x.

70. Kung RTV, Yu LS, Ochs BD, Parnis SM, Macris MP, Frazier OH. Progress in the development of the ABIOMED total artificial heart. ASAIO Journal 1995;41. https://doi.org/10.1097/00002480-199507000-00004.

71. Dissanayake TD, Budgett DM, Hu P, Bennet L, Pyner S, Booth L, et al. A novel low temperature transcutaneous energy transfer system suitable for high power implantable medical devices: Performance and validation in sheep. Artif Organs 2010;34. https://doi.org/10.1111/J.1525-1594.2009.00992.X.

72. Safe Temperature Limits in Wireless Power Transfer for Ventricular Assist Devices - Minnetronix Medical n.d. https://minnetronixmedical.com/safe-temperature-limits-in-wireless-power-transfer-for-ventricular-assist-devices/ (accessed June 23, 2025).

73. Knecht O, Kolar JW. Performance Evaluation of Series-Compensated IPT Systems for Transcutaneous Energy Transfer. IEEE Trans Power Electron 2018;34:438–51. https://doi.org/10.1109/TPEL.2018.2822722.

74. Watada M, Iwawaki K, Tamada T, Ouchi K, Takatani S, Um YS. The development of core-type Transcutaneous Energy Transmission System for artificial heart. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings 2005;7 VOLS:3849–52. https://doi.org/10.1109/IEMBS.2005.1615300.

75. Okamoto E, Yamamoto Y, Akasaka Y, Motomura T, Mitamura Y, Nosé Y. A new transcutaneous energy transmission system with hybrid energy coils for driving an implantable biventricular assist device. Artif Organs 2009;33:622–6. https://doi.org/10.1111/J.1525-1594.2009.00785.X.

76. Dal Sasso E, Bagno A, Scuri STG, Gerosa G, Iop L. The Biocompatibility Challenges in the Total Artificial Heart Evolution. Annu Rev Biomed Eng 2019;21:85–110. https://doi.org/10.1146/ANNUREV-BIOENG-060418-052432.

77. Jantzen AE, Lane WO, Gage SM, Jamiolkowski RM, Haseltine JM, Galinat LJ, et al. Use of autologous blood-derived endothelial progenitor cells at point-of-care to protect against implant thrombosis in a large animal model. Biomaterials 2011;32:8356–63. https://doi.org/10.1016/j.biomaterials.2011.07.066.

78. Noviani M, Jamiolkowski RM, Grenet JE, Lin Q, Carlon TA, Qi L, et al. Point-of-care rapid-seeding ventricular assist device with blood-derived endothelial cells to create a living antithrombotic coating. ASAIO Journal 2016;62:447–53. https://doi.org/10.1097/MAT.0000000000000351.

79. Koster A, Loebe M, Sodian R, Potapov E V., Hansen R, Müller J, et al. Heparin antibodies and thromboembolism in heparin-coated and noncoated ventricular assist devices. Journal of Thoracic and Cardiovascular Surgery 2001;121:331–5. https://doi.org/10.1067/MTC.2001.111655.

80. Hetzer R, Loebe M, Potapov E V., Weng Y, Stiller B, Hennig E, et al. Circulatory support with pneumatic paracorporeal ventricular assist device in infants and children. Annals of Thoracic Surgery 1998;66:1498–505. https://doi.org/10.1016/S0003-4975(98)00914-X.

81. Hetzer R, Weng Y, Potapov E V., Pasic M, Drews T, Jurmann M, et al. First experiences with a novel magnetically suspended axial flow left ventricular assist device. European Journal of Cardio-Thoracic Surgery 2004;25:964–70. https://doi.org/10.1016/J.EJCTS.2004.02.038.

82. Yamazaki K, Litwak P, Tagusari O, Mori T, Kono K, Kameneva M, et al. An implantable centrifugal blood pump with a recirculating purge system (Cool-Seal System). Artif Organs 1998;22:466–74. https://doi.org/10.1046/J.1525-1594.1998.06156.X

83. Snyder TA, Tsukui H, Kihara S, Akimoto T, Litwak KN, Kameneva M V., et al. Preclinical biocompatibility assessment of the EVAHEART ventricular assist device: Coating comparison and platelet activation. J Biomed Mater Res A 2007;81:85–92. https://doi.org/10.1002/JBM.A.31006.

84. Kiraly RJ, Nose Y. Natural Tissue as a Biomaterial. Biomater Med Devices Artif Organs 1974;2:207–24. https://doi.org/10.3109/10731197409118591.

85. Nose Y, Tajima K, Y I, M K, G M, Al E. Artificial heart constructed with biological material. Trans Am Soc Artif Intern Organs 1971;17:482–9.

86. Jansen P, van Oeveren W, Capel A, Carpentier A. In vitro haemocompatibility of a novel bioprosthetic total artificial heart. European Journal of Cardio-Thoracic Surgery 2012;41. https://doi.org/10.1093/EJCTS/EZS187.

87. Mohacsi P, Leprince P. The CARMAT total artificial heart. European Journal of Cardio-Thoracic Surgery 2014;46:933–4. https://doi.org/10.1093/EJCTS/EZU333.

88. Kuroda T, Kuban BD, Miyamoto T, Miyagi C, Polakowski AR, Flick CR, et al. Artificial Deep Neural Network for Sensorless Pump Flow and Hemodynamics Estimation During Continuous-Flow Mechanical Circulatory Support. ASAIO Journal 2023;69:649–57. https://doi.org/10.1097/MAT.0000000000001926.

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Приходько Юрий Михайлович Федеральное государственное бюджетное учреждение науки Институт теоретической и прикладной механики им. С.А. Христиановича Сибирского отделения Российской академии наук
Медведев Алексей Елизарович Федеральное государственное бюджетное учреждение науки Институт теоретической и прикладной механики им. С.А. Христиановича Сибирского отделения Российской академии наук
Фомин Василий Михайлович Федеральное государственное бюджетное учреждение науки Институт теоретической и прикладной механики им. С.А. Христиановича Сибирского отделения Российской академии наук
Жульков Максим Олегович Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени академика Е.Н. Мешалкина» Министерства здравоохранения Российской Федерации
Сирота Дмитрий Андреевич Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени академика Е.Н. Мешалкина» Министерства здравоохранения Российской Федерации; Федеральное государственное бюджетное образовательное учреждение высшего образования «Новосибирский государственный медицинский университет» Министерства здравоохранения Российской Федерации Российской Федерации
Протопопов Андрей Владимирович Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени академика Е.Н. Мешалкина» Министерства здравоохранения Российской Федерации
Чернявский Александр Михайлович Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени академика Е.Н. Мешалкина» Министерства здравоохранения Российской Федерации; Федеральное государственное бюджетное образовательное учреждение высшего образования «Новосибирский государственный медицинский университет» Министерства здравоохранения Российской Федерации Российской Федерации

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