Статья
Механизмы возникновения фибрилляции предсердий при COVID-19
У пациентов с COVID-19 наиболее распространенной формой аритмий является фибрилляция предсердий (ФП). Возникновение пароксизмов ФП часто по времени связано с острым периодом инфекции. При этом патофизиологические механизмы возникновения ФП, ассоциированной с COVID-19, остаются недостаточно изученными. В обзоре рассмотрены имеющиеся данные о влиянии таких факторов, как снижение доступности рецепторов ангиотензинпревращающего фермента 2, взаимодействие вируса с кластером дифференцировки 147 и сиаловой кислотой, усиленная передача сигналов воспаления, воспалительный «цитокиновый шторм», прямое вирусное повреждение эндотелия, нарушения электролитного и кислотно-щелочного баланса в острой фазе тяжелого заболевания и усиление симпатической активности.
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