Статья
Место акарбозы в лечении и профилактике сахарного диабета 2 типа. Новые возможности снижения сердечно-сосудистого риска
Неуклонный рост числа больных сахарным диабетом (СД) тип 2, отмеченный на протяжении последних десятилетий, делает проблему профилактики и лечения этого заболевания приоритетным направлением медицины. Показано, что особое внимание следует уделять раннему выявлению нарушений углеводного метаболизма, на стадии нарушения толерантности к глюкозе. Коррекция образа жизни и рациональная диетотерапия, а также использование препарата акарбозы (Глюкобая) позволяют достигнуть стойкой нормогликемии и более чем в трети случаев предупредить развитие СД. Помимо этого, лечение акарбозой положительно влияет на показатели свертывающей системы крови, липидный спектр, уменьшает дисфункцию эндотелия, выраженность оксидативного стресса, уровень инсулина и проинсулина за счет снижения постпрандиальной гликемии и инсулинорезистентности тканей. Вследствие этих эффектов отмечаются уменьшение массы тела, риска развития артериальной гипертензии, инфаркта миокарда и всех сердечно-сосудистых событий. Таким образом, целесообразно более широко использовать акарбозы у больных с предиабетом, а также у больных с СД 2 типа как в качестве монотерапии при наличии постпрандиальной гипергликемии, так и в качестве второго препарата в случае отсутствия стойкой нормогликемии. Подчеркивается, что акарбоза может сочетаться с любым сахаропонижающим препаратом. Использование акарбозы способствует превенции СД 2 типа и сердечно-сосудистых событий.
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